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News Mechanism of Action of Venopharmaceuticals and Their Use in the Treatment of Chronic Venous Insufficiency

Venopharmaceuticals are the cornerstone of conservative treatment for chronic venous insufficiency (CVD). Their mechanism of action is complex and not yet fully understood. They act on both micro -⁠ and macrocirculation, influence the tone of the venous wall, and their anti-inflammatory action is also significant.

Source: Venous Insufficiency 26. 2. 2021

News Classification and Management of Chronic Wounds

Chronic wounds are common comorbidities that increase the morbidity and mortality of patients. Common types of chronic wounds on the lower extremities include arterial, venous, and diabetic ulcers, as well as pressure ulcers. Despite their frequent occurrence, they are often poorly treated. In addition to diagnosing the etiology of chronic wounds and specific therapies, moist wound healing plays a crucial role in the treatment, such as the application of hydrocolloids and hydrogels.

Source: Wound Healing 23. 8. 2021

News MUDr. Libor Dvořáček: Microinvasiveness of surgery involves not only the method but also targeted solutions to varicose vein sources

Varicose veins, or chronic venous insufficiency of the lower extremities, are primarily a health issue, not purely a cosmetic one. This is because they are associated with the risk of complications that necessitate long-term therapy and complex treatment of these issues. As MUDr. Libor Dvořáček, the head physician of the Vasmedic Clinic, mentions in our brief interview on this topic, the approach of health insurance companies and the Ministry of Health has fortunately been changing in favor of day surgery –⁠ that is, microinvasive and much gentler surgery.

Source: Venous Insufficiency 17. 12. 2023

News Micronized Diosmin and Flavonoid Fraction –⁠ What Do They Have in Common?

Micronized diosmin and micronized purified flavonoid fraction are medications from the flavonoid group that are used as venopharmaceuticals/venoprotectives in the treatment of chronic venous insufficiency and hemorrhoidal disease. Both have many common properties, which we discuss in the following text. Their differences will be covered in a follow-up article on this topic.

Source: Venous Insufficiency 22. 2. 2021

News Sustained Remission of ITP with Thrombopoietin Receptor Agonists Treatment

Thrombopoietin receptor agonists (TPO-RAs) are highly effective drugs administered in chronic immune thrombocytopenia (ITP). Several studies have shown that they can induce remission and long-term response, even after prolonged discontinuation.

Source: Immune Thrombocytopenia 15. 9. 2020

News Overall Survival and Tolerance of Olaparib in the OlympiAD Study –⁠ Results of Extended Follow-up

Olaparib provides women with metastatic breast cancer with a germline BRCA mutation, who have not been pre-treated with chemotherapy, not only with extended progression-free survival but also, according to the latest reports, longer overall survival. Its tolerability is good over the long term.

Source: Ovarian and Breast Cancer 28. 5. 2020

News Diabetes mellitus and heart failure −⁠ interconnected units with complex pathogenesis

Diabetes mellitus (DM) represents a significant risk factor for the development of heart failure. The pathogenesis of this condition is very complex, involving hyperglycemia and other metabolic abnormalities, as well as frequently occurring comorbidities such as hypertension, ischemic heart disease, or diabetic neuropathy. The development of type 2 DM (T2DM) in patients with heart failure (cardiogenic T2DM) is also quite common and is primarily caused by the resistance of peripheral tissues to insulin. The result of cardiogenic DM is further progression and a worse prognosis of heart failure. Recent findings on this topic have been summarized by Greek experts in their review article for Journal of Clinical Medicine.

Source: Heart Failure 12. 1. 2023

News Comparison of 5 Beta-Blockers in Heart Failure with Reduced Ejection Fraction

An analysis of 26 studies with beta-blockers in the treatment of heart failure with reduced ejection fraction compared 5 drugs (bisoprolol, metoprolol-succinate, metoprolol-tartrate, carvedilol, and nebivolol). The results showed a more favorable prognosis with bisoprolol compared to carvedilol, a similar effect on prognosis for carvedilol, metoprolol-succinate, and nebivolol, and the least favorable prognosis with metoprolol-tartrate.

Source: Cardiovascular Continuum 24. 4. 2024

News Population Pharmacokinetics of Perioperative Administration of Coagulation Factors in Patients with von Willebrand Disease

For many patients with von Willebrand disease, the administration of coagulation factors is an important part of perioperative care. Due to the absence of pharmacokinetic models, predicting therapeutic levels is challenging, leading to a higher risk of bleeding or thrombotic events. To create the missing model, a long-term study was conducted by Dutch authors.

Source: Von Willebrand Disease 27. 8. 2020

Články časopisu A Contemplation about the Importance of Prosthetic Defect Classification Systems in Contemporary Dentistry

Author of the article: Z. Zdráhal, J. Krňoulová, R. Slezák Source: Česká stomatologie / Praktické zubní lékařství | 4/2012 11. 7. 2012

News PHD 2022: In the treatment of multiple myeloma we have achieved significant progress, confirm real-world data

The treatment options for multiple myeloma (MM) have significantly advanced over the past 10 years, and patient outcomes have improved. However, the most accurate guide is needed to select the right treatment modality for each particular patient among the many available options. During the Prague Hematology Days (PHD) 2022, this topic was addressed by Prof. MUDr. Roman Hájek, CSc., from the Hemato-Oncology Clinic of the Faculty of Medicine at the University of Ostrava and FN Ostrava.

Source: Hematologic Malignancies 28. 3. 2022

News Gliflozins in the Treatment of Type 2 Diabetes According to Current Recommendations SVL

Gliflozins are a relatively new group of antidiabetics with a specific mechanism of action. In addition to glycemic control, they have shown favorable effects on body weight and blood pressure, minimal risk of hypoglycemia, reduced risk of heart failure, and also renal protection and cardiovascular safety. Their position in the therapeutic algorithm for type 2 diabetes is clearly defined in the 2020 recommendations of the Society of General Medicine ČLS JEP.

Source: Diabetes 24. 11. 2020

News Does Dosage Frequency Matter for Adherence to Anticholinergic Treatment in Patients with COPD?

A study by Spanish authors compared the adherence of patients with chronic obstructive pulmonary disease (COPD) to anticholinergic treatment administered once every 12 hours and once every 24 hours.

Source: Treatment of Asthma and COPD 15. 5. 2020

News Severe Polytrauma in a Man with von Willebrand Disease −⁠ Case Report

The authors of a recently published case report present a case of multiple trauma (including brain injury) in a young man with von Willebrand disease (vWD) type 2A, in whom repeated administration of a concentrate containing von Willebrand factor (vWF) and coagulation factor VIII (FVIII) led to successful healing without neurological deficit.

Source: Von Willebrand Disease 29. 11. 2022

News Current NCCN Recommendations for Classification and Risk Symptoms in SLL/CLL

The new recommendations from the National Comprehensive Cancer Network (NCCN) regarding chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) from August 2022 also include a brief summary of the most common symptoms and methods for classifying the disease based on its extent at diagnosis or in case of progression.

Source: Chronic Lymphocytic Leukemia 12. 1. 2023