#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Multiple lymph node plasmacytosis with monoclonal gammopathy – plasma cell neoplasm or indolent B-lymphoma?


Authors: Z. Král 1;  Marta Krejčí 1;  L. Říhová 2;  L. Křen 3;  Z. Řehák 4;  R. Koukalová 4;  L. Pour 1;  M. Štork 1;  Martin Krejčí 1;  V. Sandecká 1;  Z. Čermáková 5;  Z. Adam 1
Authors‘ workplace: Interní hematologická a onkologická klinika LF MU a FN Brno 1;  Oddělení klinické hematologie, LF MU a FN Brno 2;  Ústav patologie, LF MU a FN Brno 3;  Oddělení nukleární medicíny, Masarykův onkologický ústav Brno 4;  Oddělení klinické bio­chemie, LF MU a FN Brno 5
Published in: Transfuze Hematol. dnes,27, 2021, No. 3, p. 262-265.
Category: Case Report
doi: https://doi.org/10.48095/cctahd2021262

Overview

We describe the clinical course, dia­gnosis and therapy of a rare case of indolent plasma cell proliferation with multiple involvement of lymph nodes and monoclonal gammopathy. At first, a dia­gnosis of plasma cell neoplasm with generalised lymphadenopathy and without significant bone marrow infiltration was considered. However, repeated examination of the lymph nodes and bone marrow changed the dia­gnosis to indolent marginal zone B-cell lymphoma with plasmacytic differentiation was rather than extramedullary nodal plasmacytoma.

Keywords:

plasmacytoma – indolent lymphoma with plasmacytic differentiation


Sources
  1. Swerdlow SH, Campo E, Harris NL, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th edition, Lyon, 2008, 439 pgs.
  2. Swerdlow SH, Campo E, Harris NL, et al. WHO classification of tumours of hematopoietic and lymphoid tissues. Revised 4th edition, Lyon, 2017, 585 pgs.
  3. Hrabovský Š, Řehák Z, Stulík J, et al. Raritní případ mnohočetného myelomu: vícečetný solitární plazmocytom kostí bérců a předloktí. Vnitř Lék. 2015; 61: 161–165.
  4. Pika T, Minařík J, Ščudla, V, et al. Solitární kostní plazmocytom. Osteologický Bulletin. 2012; 17: 136–142.
  5. Vošmik M, Maisnar V. Solitární extramedulární plazmocytom – dia­gnostika a léčba. Klin Bioch Metabol. 2007; 15/36: 82–84.
  6. Radocha J, Maisnar V. Solitární kostní plazmocytom – kazuistika. Klin Bioch Metabol. 2007; 15/36: 89–90.
  7. Bačovský J. Solitární plazmocytom. Int Med Prax. 2005; 7: 444–446.
  8. Fabián P. Odpověď: Solitární extraoseální plazmocytom. Česko-slovenská patologie a Soudní Lék. 2008; 115: 44–53.
  9. Ščudla V, Minařík J, Pika T, et al. Diferenciální dia­gnostika monoklonálních gamapatií z pohledu klinické praxe. I. Maligní monoklonální gamapatie. Int Med Prax. 2017; 19: 274–278.
  10. Dores GM, Landgren O, McGlynn KA, et al. Plasmacytoma of bone, extramedullary plasmacytoma, and multiple myeloma: incidence and survival in the United States, 1992-2004. Br J Haematol. 2009; 144: 86–94.
  11. Gavriatopoulou M, Musto P, Hájek R, et al. European Myeloma Network recommendations on dia­gnosis and management of patients with rare plasma cell dyscrasias. Leukemia. 2018; 32: 1883–1898.
  12. Dia­gnostika a léčba mnohočentého myelomu. Doporučení vypracované Českou myelomovou skupinou. Transfuze Hematol Dnes. 2018; 24 (Suppl. 1): 1–150.
  13. Gerry D, Lentsch EJ. Epidemiologic evidence of superior outcomes for extramedullary plasmacytoma of the head and neck. Otolaryngol Head Neck Surg. 2013; 148: 974–981.
  14. Menke DM, Horny HP, Griesser H, et al. Primary lymph node plasmacytomas (plasmacytic lymphomas). Am J Clin Pathol. 2001; 115: 119–126.
  15. Kilciksiz S, Karakoyun-Celik O, Agaoglu FY, et al. A review for solitary plasmacytoma of bone and extramedullary plasmacytoma. ScientificWorld J. 2012; 2012: 895765. doi: 10.1100/2012/895765.
  16. Salem KZ, Nishihori T, Kharfan-Dabaja MA, et al. Primary plasmacytoma involving mediastinal lymph nodes: A dia­gnostic mimicry of primary mediastinal lymphoma. Hematol Oncol Stem Cell Ther. 2016; 9: 26–29.
  17. Matsushima T, Murakami H, Tamura J, et al. Primary plasmacytoma of generalized lymph nodes: a long survivor. Am J Hematol. 1993; 43: 237–239.
  18. Gorodetskiy VR, Probatova NA, Vasilyev VI. Unusual course of generalized lymph node primary plasmacytoma in a patient with Sjogren‘s syndrome: a case report. J Med Case Rep. 2017; 11: 116. doi: 10.1186/s13256-017-1266-7.
  19. Lim YH, Park SK, Oh HS, et al. A case of primary plasmacytoma of lymph nodes. Korean J Intern Med. 2005; 20: 183–186.
  20. Lin BT, Weiss LM. Primary plasmacytoma of lymph nodes. Hum Pathol. 1997; 28: 1083–1090.
  21. Naymagon L, Abdul-Hay M. Primary extramedulary plasmocytoma with diffuse lymph node involvement: a case report and review of literature. J Med Case Rep. 2019; 13: 153.
  22. Harmon CM, Smith LB. Plasmablastic lymphoma: a review of clinicopathologic features and differential dia­gnosis. Arch Pathol Lab Med. 2016; 140 (10): 1074–1078.
  23. Harmon CM, Smith LB. B-cell non-Hodgkin lymphomas with plasmacytic differentiation. Surg Pathol Clin. 2016; 9: 11–28.
Labels
Haematology Internal medicine Clinical oncology
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#