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Plasma cell leukaemia


Authors: T. Jelínek;  H. Plonková;  R. Hájek
Authors‘ workplace: Lékařská fakulta, Ostravská univerzita v Ostravě ;  Klinika hematoonkologie, Fakultní nemocnice Ostrava
Published in: Transfuze Hematol. dnes,19, 2013, No. 3, p. 152-162.
Category: Comprehensive Reports, Original Papers, Case Reports

Overview

Plasma cell leukaemia (PCL) is a rare and aggressive variant of plasma cell dyscrasias characterized by the presence of circulating plasma cells. It is classified as either primary PCL occurring “de novo” or as secondary PCL in patients with relapsed/refractory myeloma. Primary PCL is a distinct clinicopathological entity with different cytogenetic and molecular findings. The clinical course is aggressive with short remissions and survival. The diagnosis is based upon the percentage (> 20%) and absolute number (2 x 109/l) of plasma cells in the peripheral blood. Induction therapy needs to begin promptly and to have high clinical activity leading to rapid disease control. Intensive chemotherapy regimens and bortezomib-based regimens are recommended followed by high-dose therapy with autologous stem cell transplantation if feasible. Allogeneic transplantation can be considered in younger patients. This work reviews recent knowledge of this blood malignancy with very poor prognosis.

Keywords:
plasma cell leukaemia, transplantation, myeloma, bortezomib


Sources

1. Sant M, Allemani C, Tereanu C, et al. Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project. Blood 2010; 116: 3724-3734.

2. Dimopoulos MA, Palumbo A, Delasalle KB, Alexanian R. Primary plasma cell leukaemia. Br J Haematol 1994; 88: 754-759.

3. Tiedemann RE, Gonzalez-Paz N, Kyle RA, et al. Genetic aberrations and survival in plasma cell leukemia. Leukemia 2008; 22: 1044-1052.

4. Yamamoto JF, Goodman MT. Patterns of leukemia incidence in the United States by subtype and demographic characteristics, 1997-2002. Cancer Causes Control 2008; 19: 379-390.

5. Fernandez C, Kyle RA, Durie BGM, Lidwig H, Usmani S. Plasma cell leukemia: Consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group, Leukemia 2013; 27: 780-791.

6. Kyle RA, Maldonado JE, Bayrd ED. Plasma cell leukemia. Report on 17 cases. Arch Intern Med 1974; 133: 813-818.

7. Noel P, Kyle RA. Plasma cell leukemia: an evaluation of response to therapy. Am J Med 1987; 83: 1062-1068.

8. Bladé J, Kyle RA. Nonsecretory myeloma, immunoglobulin D myeloma, and plasma cell leukemia. Hematol Oncol Clin North Am 1999; 13: 1259-1272.

9. García-Sanz R, Orfao A, González M, et al. Primary plasma cell leukemia: clinical, immunophenotypic, DNA ploidy, and cytogenetic characteristics. Blood 1999; 93: 1032-1037.

10. Pagano L, Valentini CG, De Stefano V, et al. Primary plasma cell leukemia: a retrospective multicenter study of 73 patients. Ann Oncol 2011; 22: 1628-1635.

11. Kyle RA. Multiple myeloma: review of 869 cases. Mayo Clin Proc 1975; 50: 29-40.

12. Dimopoulos MA, Barlogie B, Smith TL, Alexanian R. High serum lactate dehydrogenase level as a marker for drug resistance and short survival in multiple myeloma. Ann Intern Med 1991; 115: 931-935.

13. Kumar S, Rajkumar SV, Kyle RA, et al. Prognostic value of circulating plasma cells in monoclonal gammopathy of undetermined significance. J Clin Oncol 2005; 23: 5668-5674.

14. Nowakowski GS, Witzig TE, Dingli D, et al. Circulating plasma cells detected by flow cytometry as a predictor of survival in 302 patients with newly diagnosed multiple myeloma. Blood 2005; 106: 2276-2279.

15. Shtalrid M, Shvidel L, Vorst E. Polyclonal reactive peripheral blood plasmacytosis mimicking plasma cell leukemia in a patient with Staphylococcal sepsis. Leuk Lymphoma 2003; 44: 379-380.

16. Touzeau C, Pellat-Deceunynck C, Gastinne T, et al. Reactive plasmacytoses can mimick plasma cell leukemia: therapeutical implications. Leuk Lymphoma 2007; 48: 207-208.

17. Al-Sahmani M, Trnavska I, Sevcikova S, et al. Prognostic significance of morphological assessment of plasma cells in multiple myeloma, Neoplasma 2011, 58: 554-560.

18. Pellat-Deceunynck C, Barillé S, Jego G, et al. The absence of CD56 (NCAM) on malignant plasma cells is a hallmark of plasma cell leukemia and of a special subset of multiple myeloma. Leukemia 1998; 12:1977-1982.

19. Guikema JE, Vellenga E, Abdulahad WH, Hovenga S, Bos NA. CD27triggering on primary plasma cell leukaemia cells has anti--apoptotic effects involving mitogen activated protein kinases. Br J Haematol 2004; 124: 299-308.

20. Guikema JE, Hovenga S, Vellenga E, et al. CD27 is heterogeneously expressed in multiple myeloma: low CD27 expression in patients with high-risk disease. Br J Haematol 2003; 121: 36-43.

21. Walters M, Olteanu H, Van Tuinen P, Kroft SH. CD23 expression in plasma cell myeloma is specific for abnormalities of chromosome 11, and is associated with primary plasma cell leukaemia in this cytogenetic sub-group. Br J Haematol 2010; 149: 292-293.

22. van de Donk NW, Lokhorst HM, Anderson KC, Richardson PG. How I treat plasma cell leukemia, Blood 2012; 120: 2376-2389.

23. Chang H, Yeung J, Xu W, Ning Y, Patterson B. Significant increase of CKS1B amplification from monoclonal gammopathy of undetermined significance to multiple myeloma and plasma cell leukaemia as demonstrated by interphase fluorescence in situ hybridisation. Br J Haematol 2006; 134: 613-615.

24. Bezieau S, Devilder MC, Avet-Loiseau H, et al. High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis. Hum Mutat 2001; 18: 212-224.

25. Urashima M, Teoh G, Ogata A, et al. Characterization of p16(INK4A) expression in multiple myeloma and plasma cell leukemia. Clin Cancer Res 1997; 3: 2173-2179.

26. Mateos MV, Garcia-Sanz R, López-Pérez R, et al. p16/INK4a gene inactivation by hypermethylation is associated with aggressive variants of monoclonal gammopathies. Hematol J 2001; 2: 146-149.

27. Bollati V, Fabris S, Pegoraro V, et al. Differential repetitive DNA methylation in multiple myeloma molecular subgroups. Carcinogenesis 2009; 30: 1330-1335.

28. Usmani SZ, Nair B, Qu P, et al. Primary plasma cell leukemia: clinical and laboratory presentation, gene-expression profiling, and clinical outcome with Total Therapy protocols. Leukemia, 2012; 26: 2398-2405.

29. Egan JB, Shi CX, Tembe W, et al. Whole genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution and clonal tides. Blood 2012; 120: 1060-1066.

30. Mitsiades CS, McMillin DW, Klippel S, et al. The role of bone marrow microenvironment in the pathophysiology of myeloma and its significance in the development of more effective therapies. Hematol Oncol Clin North Am 2007; 21: 1007-1034.

31. Luque R, García-Trujillo JA, Cámara C, et al. CD106 and activated-CD29 are expressed on myelomatous bone marrow plasma cells and their downregulation is associated with tumour progression. Br J Haematol 2002; 119: 70-78.

32. Kraj M, Kopeć-Szlęzak J, Pogłód R, Kruk B. Flow cytometric immunophenotypic characteristics of 36 cases of plasma cell leukemia. Leuk Res 2011; 35: 169-76.

33. Pérez-Andrés M, Almeida J, Martín-Ayuso M, et al. Clonal plasma cells from monoclonal gammopathy of undetermined significance, multiple myeloma and plasma cell leukemia show different expression profiles of molecules involved in the interaction with the immunological bone marrow microenvironment. Leukemia 2005; 19: 449-455.

34. Vande Broek I, Vanderkerken K, Van Camp B, Van Riet. Extravasation and homing mechanisms in multiple myeloma. Clin Exp Metastasis 2008; 25: 325-334.

35. Zhang XG, Bataille R, Widjenes J, Klein B. Interleukin-6 dependence of advanced malignant plasma cell dyscrasias. Cancer 1992; 69: 1373-1376.

36. Bladé J, López-Guillermo A, Tassies D, Montserrat E, Rozman C. Development of aggressive plasma cell leukaemia under interferon--alpha therapy. Br J Haematol 1991; 79: 523-525.

37. Fišerová B, Kubiczková L, Sevčíková S, Hájek R. Implication of bone marrow microenvironment in pathogenesis of multiple myeloma. Klin Onkol 2012; 25: 234-240.

38. Duprez R, Lacoste V, Hermouet S, et al. Plasma-cell leukemia and human herpesvirus 8 infection. Leukemia 2004; 18: 1903-1904.

39. Hermouet S, Corre I, Gassin M, Bigot-Corbel E, Sutton CA, Casey JW. Hepatitis C virus, human herpesvirus 8, and the development of plasma-cell leukemia. N Engl J Med 2003; 348: 178-179.

40. Döhner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European Leukemia Net. Blood 2010; 115: 453-474.

41. Colović M, Janković G, Suvajdzić N, Milić N, Dordević V, Janković S. Thirty patients with primary plasma cell leukemia: a single center experience. Med Oncol 2008; 25: 154-160.

42. Peijing Q, Yan X, Yafei W. A retrospective analysis of thirty-one cases of plasma cell leukemia from a single center in China. Acta Haematol 2009; 121: 47-51.

43. Ramsingh G, Mehan P, Luo J, Vij R, Morgensztern D. Primary plasma cell leukemia: a Surveillance, Epidemiology, and End Results database analysis between 1973 and 2004. Cancer 2009; 115: 5734-5739.

44. Mahindra A, Kalaycio ME, Vela-Ojeda J, et al. Hematopoietic cell transplantation for primary plasma cell leukemia: results from the Center for International Blood and Marrow Transplant Research. Leukemia 2012; 26: 1091-1097.

45. Avet-Loiseau H, Daviet A, Brigaudeau C, et al. Cytogenetic, interphase, and multicolor fluorescence in situ hybridization analyses in primary plasma cell leukemia: a study of 40 patients at diagnosis, on behalf of the Intergroupe Francophone du Myélome and the Groupe Français de Cytogénétique Hématologique. Blood 2001; 97: 822-825.

46. Saccaro S, Fonseca R, Veillon DM, et al. Primary plasma cell leukemia: report of 17 new cases treated with autologous or allogeneic stem-cell transplantation and review of the literature. Am J Hematol 2005; 78: 288-294.

47. D’Arena G, Valentini CG, Pietrantuono G, et al. Frontline chemotherapy with bortezomib-containing combinations improves response rate and survival in primary plasma cell leukemia: a retrospective study from GIMEMA Multiple Myeloma Working Party. Ann Oncol 2012; 23: 1499-1502.

48. Drake MB, Iacobelli S, van Biezen A, et al. European Group for Blood and Marrow Transplantation and the European Leukemia Net. Primary plasma cell leukemia and autologous stem cell transplantation. Haematologica 2010; 95: 804-809.

49. Attal M, Lauwers-Cances V, Marit G, et al. Lenalidomide maintenance after stem-cell transplantation for multiple myeloma. N Engl J Med 2012; 366: 1782-1791.

50. Morris C, Iacobelli S, Gahrton G, et al. Has allogeneic transplantation a role in the management of plasma cell leukaemia? A study on behalf of the Myeloma Subcomittee of the Chronic Leukaemia Working Party of the EBMT. Blood (ASH Annual Meeting Abstracts) 2011; 118: Abstract 2008.

51. Petrucci MT, Martini V, Levi A, et al. Thalidomide does not modify the prognosis of plasma cell leukemia patients: experience of a single center. Leuk Lymphoma 2007; 48: 180-182.

52. Pretz J, Medeiros BC. Thalidomide-induced pneumonitis in a patient with plasma cell leukemia: no recurrence with subsequent lenalidomide therapy. Am J Hematol 2009; 84: 698-699.

53. Ballanti S, Mastrodicasa E, Bolli N, et al. Sustained ventricular tachycardia in a thalidomide-treated patient with primary plasma-cell leukemia. Nat Clin Pract Oncol 2007; 4: 722-725.

54. Musto P, Pietrantuono G, Guariglia R, et al. Salvage therapy with lenalidomide and dexamethasone in relapsed primary plasma cell leukemia. Leuk Res 2008; 32: 1637-1638.

55. Olivieri A, Attolico I, Cimminiello M, Discepoli G, Cifarelli RA. Lenalidomide can induce graft versus leukemia effect in primary plasma cell leukemia: a case report. Leuk Res 2009; 33: 191-193.

56. Musto P, D’Auria F, Petrucci MT, et al. Final results of a phase II study evaluating lenalidomide in combination with low dose dexamethasone as first line therapy for primary plasma cell leukemia. Blood (ASH Annual Meeting Abstracts), 2011; 118: Abstract 2925.

57. Esparis-Ogando A, Alegre A, Aguado B, et al. Bortezomib is an effi-cient agent in plasma cell leukemias. Int J Cancer 2005; 114: 665-667.

58. Musto P, Rossini F, Gay F, et al. Efficacy and safety of bortezomib in patients with plasma cell leukemia. Cancer 2007; 109: 2285-2290.

59. Lebovic D, Zhang L, Alsina M, et al. Clinical outcomes of patients with plasma cell leukemia in the era of novel therapies and hematopoietic stem cell transplantation strategies: a singleinstitution experience. Clin Lymphoma Myeloma Leuk 2011; 11: 507-511.

60. Libby E, Candelaria-Quintana D, Moualla H, Abdul-Jaleel M, Rabinowitz I. Durable complete remission of primary plasma cell leukemia with the bortezomib plus melphalan and prednisone (VMP) regimen. Am J Hematol 2010; 85: 733-734.

61. Al-Nawakil C, Tamburini J, Bardet V, et al. Borderline, doxorubicin and dexamethasone association is an effective option for plasma cell leukemia induction therapy. Leuk Lymphoma 2008; 49: 2012-2014.

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