A review of medical studies on drug interactions and risk combination of drugs in prescription of physicians
Authors:
M. Prokeš
Authors‘ workplace:
Infopharm, a. s., Praha
Published in:
Listy rev. Lék., 13, 2009, č. 1, s. 3-15
Overview
Drug interactions are one of the main risks of pharmacotherapy in all advanced countries of the world. In this article, a review of studies identifying the incidence of drug interactions and other risk combinations of drugs is presented. The study in Great Britain found that 6,5% of hospital admissions were caused by adverse drug reactions, of which 16,6% were caused by drug interactions. Even higher rate of drug interactions was detected in patients admitted to the intensive care unit in one of the New York hospitals. Furthermore, the review of nine studies is presented, which describes data collection and data evaluation of the follow-up of risk prescription at the out-patient medical practice and also methods of influencing prescription of physicians with the aim to increase the safe treatment in France, USA, Great Britain, Canada, Czech Republic, Spain and Israel. In some of these studies, the support of rational pharmaco-therapy is described. In the discussion to these findings, some methods are proposed to increase safety of pharmacotherapy in the Czech Republic.
Key words:
drug interactions – safety of pharmacotherapy – identification of risk prescription – database of prescribed drugs
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Medical assessment Occupational medicineArticle was published in
Revision Medicine Journal
2009 Issue 1
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