Intraoperative sentinel lymph node detection in colon cancer resection – preliminary results
Authors:
J. Cagaš 1; I. Čapov 1; P. Vlček 1; J. Korbička 1; L. Veverková 1; M. Hermanová 2; M. Tichý 2
Authors‘ workplace:
I. chirurgická klinika LF MU a FN U sv. Anny v Brně, přednosta: prof. MUDr. I. Čapov CSc.
1; I. patologicko-anatomický ústav LF MU a FN U sv. Anny v Brně, přednosta: prof. MUDr. M. Hermanová, PhD.
2
Published in:
Rozhl. Chir., 2015, roč. 94, č. 4, s. 156-159.
Category:
Original articles
Overview
Introduction:
The aim of this paper is to evaluate the results of intraoperative sentinel node detection in colon cancer patients and to compare the number of nodes retrieved per specimen in comparison with standard resection.
Methods:
Patients undergoing elective colon cancer resection were included in the study. The specimen and the sentinel lymph node were sent for histopathological examination. A group of patients from 2011 who underwent elective resection served as the study control.
Results:
The control group comprised 56 patients. The average node count was 12.73 (4–27). The study group included 102 patients; 29 patients had to be excluded because of protocol deviation. Out of the remaining 73 (46 male and 27 female) patients, 24 were N-positive and 2 of them were pN1c. In the remaining 22 patients, the sentinel node was positive in 8 cases, corresponding to a sensitivity of 36.36%. The average lymph node count was 15.97(3–30) after patent blue dye injection.
Conclusion:
Intraoperative sentinel lymph node detection is an easy and feasible method. Despite the low sensitivity, the main positive effect of the method is the increased lymph node count per resection specimen.
Key words:
sentinel node − colon cancer − intraoperative detection
Sources
1. Duben J, Dudešek B, Hnátek L, et al. Lymfatické mapování a biopsie sentinelových uzlin s použitím kombinované metodiky in vivo aplikace Patentblue a radionuklidu a ex vivo detekce metastatického postižení lymfatických uzlin u kolorektálního karcinomu. Rozhl Chir 2010;89:695−701.
2. Tan KY, Kawamura YJ, Mizokami K, et al. Distribution of the first metastatic lymph node in colon cancer and its clinical significance. Colorectal Dis 2010;12:44−7.
3. Kelder W, Braat AE, Karrenbeld A, et al. The sentinel node procedure in colon carcinoma: A multi-centre study in The Netherlands. Int J Colorectal Dis 2007;22:1509−14.
4. Bembenek AE, Rosenberg R, Wagler E, et al. Sentinel lymph node biopsy in colon cancer: a prospective multicenter trial. Ann Surg 2007;245:858–63.
5. Merrie AE, van Rij AM, Phillips LV, et al. Diagnostic use of the sentinel node in colon cancer. Dis Colon Rectum 2001;44:410−7.
6. Saha S, Wiese D, Badin J, et al. Technical details of sentinel lymph node mapping in colorectal cancer and its impact on staging. Ann Surg Oncol 2000;7:120−4.
7. Broderick-Villa G, Ko A, O‘Connell TX, et al. Does tumor burden limit the accuracy of lymphatic mapping and sentinel lymph node biopsy in colorectal cancer? Cancer J 2002;8:445-50.
8. Sommariva A, Donisi PM, Gnocato B, et al. Factors affecting false-negative rates on ex vivo sentinel lymph node mapping in colorectal cancer. Eur J Surg Oncol 2010;36:130−4.
9. van der Zaag ES, Bouma WH, Tanis PJ, et al. Systematic review of sentinel lymph node mapping procedure in colorectal cancer. Ann Surg Oncol. 2012;19:3449−59.
10. van der Zaag ES, Bouma WH, Peters HM, et al. Implications of sentinel lymph node mapping on nodal staging and prognosis in colorectal cancer. Colorectal Dis 2012;14:684−90.
11. Hirche C, Mohr Z, Kneif S, et al. Ultrastaging of colon cancer by sentinel node biopsy using fluorescence navigation with indocyanine green. Int J Colorectal Dis 2012;27:319−24.
12. Cahill RA, Anderson M, Wang LM, et al. Near-infrared (NIR) laparoscopy for intraoperative lymphatic road-mapping and sentinel node identification during definitive surgical resection of early-stage colorectal neoplasia. Surg Endosc 2012;27:197−204.
13. Wakeman C, Yu V, Chandra R, et al. Lymph node yield following injection of patent blue V dye into colorectal cancer specimens. Colorectal Dis 2011;13:266−9.
Labels
Surgery Orthopaedics Trauma surgeryArticle was published in
Perspectives in Surgery
2015 Issue 4
Most read in this issue
- The ONSTEP inguinal hernia repair technique
- Massive small intestine bleeding: CT-angiography and surgical treatment – a case report
- Acute necrotizing pancreatitis: traditional laparotomy vs. minimally invasive procedures
- The past and present of thumb reconstruction