Selenium Supplementation in Patients with Severe Acute Pancreatitis
Authors:
L. Kočan; J. Firment; J. Šimonová; J. Vašková; J. Guzy
Authors‘ workplace:
Slovenská republika, prednosta kliniky: doc. MUDr. Jozef Firment, Ph. D.
; I. klinika anesteziológie a intenzívnej medicíny, Univerzálna nemocnica L. Pasteura, Košice
Published in:
Rozhl. Chir., 2010, roč. 89, č. 8, s. 518-521.
Category:
Monothematic special - Original
Overview
Selenium supplementation improves antioxidant status in critically ill patients with severe acute pancreatitis. It depends on quantum of dosage and supplementation time. The aim of this analysis is point out on benefit of antioxidant therapy by supplementing selenium.
Methods:
Patient with severe acute pancreatitis and developing septic shock was admitted on anesthesiology and intensive care department. Adjuvant supplementation therapy with selenium was started in continual infusion 750 mg/24 h during next six days. Activity of antioxidant enzyme glutathione peroxidase and others inflammatory markers were decrease.
A case report presents the possibility to affect on systemic inflammatory response syndrome pathogenesis in initial phase. It has to improve therapeutic progress in patients with severe acute pancreatitis.
Key words:
severe acute pancreatitis – sepsis – systemic inflammatory response syndrome – selenium – glutathione peroxidase
Sources
1. Rau, B M., Krüger, C. M., Hasel, C., Oliveira, V., Rubie, C., Beger, H. G., a kol. Effects of immunosuppressive and immunostimulative treatment on pancreatic injury and mortality in severe acute experimental pancreatitis. Pancreas, 2006; č. 33, s. 174–183.
2. Rau, B. M.,, Bothe, A., Kron, M., Beger H. G. Role of early multisystem organ failure as major risk factor for pancreatic infections and death in severe acute pancreatitis. Clin. Gastroenterol. Hepatol., 2006; č. 4: s. 1053–1061.
3. Lakyová L., Toncr, Radoňak J., Šimon, R., Toporcer, T., Vajó, J., Belák, J. Spontánna perforácia ductus choledochus pri akútnej pankreatitíde – kazuistika. Rozhl. Chir., 2008, roč. 87, č. 2, s. 92–95.
4. Balthazar, E. J: Staging of acute pancreatitis. Radiologic clinics of North America, 2002; 40 (6): s. 1199–1209.
5. Geoghegan, M., McAuley, D., Eaton, S., Powel-Tuck, J. Selenium in critical illness. Critical Care, 2006, 12, s. 136–141.
6. Nathens, B. A., Curtis, R. J., Beale, J. R., et al. Management of the critically ill patient with severe acute pankreatitis. Critical Care Medicine, 2004, roč. 32, č. 12, s. 2524–2536.
7. Heyland, D., Dhaliwal, R., Suchner, U., Berger, M. M. Antioxidant nutrients: a systematic review of trace elements and vitamins in the critically ill patient. Intensive Care Medicine, 2005, roč. 31, str. 327–337.
8. Heyland, D., Dhaliwal, R., Day, A., Drover, J., Cote, H., Wischmeyer, P. Optimizing the dose of glutamine dipeptides and antioxidants in critically ill patients: a phase I dose-finding study. J. Parenteral Enteral Nutrition, 2007, roč. 31, s. 109–118.
9. Berger, M., Chiolero, R. Antioxidant supplementation in sepsis and systematic inflammatory response syndrome. Critical Care Medicine, 2007; roč. 35, s. 584–590.
10. Angstwurm, M. W. A., Schottdorf, J., Schopohl, J., Gaertner, R. Selenium replacement in patients with severe systemic inflammatory response syndrome improves clinical outcome. Critical Care Medicine, 1999, roč. 27, s. 1807–1813.
11. Sakr, Y., Reinhart, K., Bloos, F., Marx, G., Russwurm, S., Bauer, M., Brunkhorst, F. Time course and relationship between plasma selenium concentrations, systemic inflammantory response, sepsis, and multiorgan failure. Br. J. Anaesth., 2007, roč. 98, s. 775–784.
12. Forceville, X., Vitoux, D., Gauzit, R., Combes, A., Lahilaire, P., Chappuis, P. Selenium, systemic immune response syndrome, sepsis, and outcome in critically ill patients. Critical Care Medicine, 1998, roč. 26, s. 1536–1544.
13. Salama, A., Sakr, Y., Reinhart, K. The role of selenium in critical illness: Basic science and clinical implications. Critical Care Medicine, 2007, roč. 7, s. 127–138.
14. Kuklinski, B., Buchner, M., Schweder, R., Nagel, R. Akute Pancreatitis-eine „Free Radical Disease: Letalitatssenkung durch Natriumselenit (Na2SeO3)-Therapie. Z Gestame Inn. Med., 1991, 46: s. 145–149.
15. Forceville, X. Seleno-enzymes and seleno-compounds: the two faces of selenium. Critical Care, 2006, roč. 10, s. 180.
16. Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., van Remmen, H. Trends in oxidative aging theories. Free Radic. Biol. Med., 2007, roč. 43, s. 477–503.
17. Záhorec, R. Pomer neutrofilov a lymfocytov - rýchly a jednoduchý ukazovateľ systémového zápalu a stresu u pacientov v kritických stavoch; Bratislavské Lekárske Listy, 2001, č. 102: s. 5–14.
Labels
Surgery Orthopaedics Trauma surgeryArticle was published in
Perspectives in Surgery
2010 Issue 8
Most read in this issue
- Syndroma Caudae Equinae of Rare Etiology
- Possibilities and Results of Surgical Treatment of Benign Tracheoesophageal Fistula
- How Long to Wait with Operations for Necrotizing Pancreatitis?
- Urgent Thyroidectomy for a Mechanical Syndrome Caused by a Toxic Nodular Goiter – A Case Report