Intraoperative Radiotherapy in Multimodality Treatment of Locally Advanced Rectal Carcinoma
Authors:
R. Soumarová; M. Škrovina *; S. Machala; L. Adamčík *; J. Bartoš *
Authors‘ workplace:
Oddělení radioterapie a onkologie, Komplexní onkologické centrum Nový Jičín
primářka: doc. MUDr. R. Soumarová, Ph. D.
; Chirurgické oddělení nemocnice Nový Jičín, Komplexní onkologické centrum Nový Jičín
primář: MUDr. M. Škrovina
*
Published in:
Rozhl. Chir., 2010, roč. 89, č. 11, s. 685-688.
Category:
Monothematic special - Original
Overview
Multimodality treatment of locally advanced rectal cancer combines radical surgery, radiotherapy and chemotherapy. This method leads to improvement of local control and overall survival. However, some of the patients incur local failure of disease, which are localized predominantly in presacral region. The integration of intraoperative radiotherapy as part of a multimodal treatment approach helps to a further dose escalation without increasing toxicity, and reduces the likelihood of otherwise difficult curable local failure.
Key words:
locally advanced rectal cancer – intraoperative radiation therapy – multimodality treatment
Sources
1. Camma, C., Grunta, M., Fiorica, F., et al. Preoperative radiotherapy for resectable rectal cancer: A meta-analysis. JAMA, 2000; 284: 1008–1015.
2. Glimelius, B., Isacsson, U., Jung, B., et al. Radiotherapy in addition to radical surgery in rectal cancer: Evidence for a dose-response effect favoring preoperative treatment. Int. J. Radiat. Oncol. Biol. Phys., 1997; 37: 281–287.
3. Tepper, J. E., O’Connell, M., Niedzwiecki, D., et al. Adjuvant therapy in rectal cancer: Analysis of stage, sex, and local control – Final report of intergroup 0114. J. Clin. Oncol., 2002; 20: 1744–1750.
4. Kapiteijn, E., Marijnen, C. A., Nagtegaal, I. D., et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N. Engl. J. Med., 2001; 345: 638–646.
5. Lindel, K., Willett, C. G., Shellito, P. C., et al. Intraoperative radiation therapy for locally advanced recurrent rectal or rectosigmoid cancer. Radiother. Oncol., 2001; 58(1): 83–87.
6. Yu, T. K., Bhosale, P. R., Crane, C. H., et al. Patterns of locoregional recurrence after surgery and radiotherapy or chemoradiation for rectal cancer. Int. J. Radiat. Oncol. Biol. Phys., 2008, 15; 71(4): 1175–1180.
7. Hoffman, J. P., Rilly, L., Carp, N. Z., Litwin, S. Isolated locally recurrent rectal cancer: a review of incidence, presentation, and management. Semin. Oncol., 1993; 20: 506–519.
8. Nuyttens, J. J., Kolkman-Deurloo, I. K., Vermaas, M., et al. Highdose-rate intraoperative radiotherapy for close or positive margine in patients with locally advanced or recurrent rectal cancer. Int. J. Radiat. Oncol. Biol. Phys., 2004; 58: 106–112.
9. Willett, C. G., Czito, B. G., Tyler, D. S. Intraoperative radiation therapy. J. Clin. Oncol., 2007; 25: 971–977.
10. Roeder, F., Treiber, M., Oertel, S., et al. Patterns of failure and local control after intraoperative electron boost radiotherapy to the presacral space in combination with total mesorectal exciton in patients with locally advanced rectal cancer. Int. J. Radiat. Oncol. Biol. Phys., 2007; 67: 1381–1388.
11. Calvo, F. A., Gomez-Espi, M., Diaz-Gonzalez, J. A., et al. Intraoperative presacral electron boost following preoperative chemoradiation in T3-4Nx rectal cancer: initial local effects and clinical outcome analysis. Radiother. Oncol., 2002; 62: 201–206.
12. Mannaerts, G. H., Martijn, H., Crommelin, M. A., et al. Feasibility and first results of multimodality treatment, combining EBRT, extensive surgery, and IOERT in locally advanced primary rectal cancer. Int. J. Radiat. Oncol. Biol. Phys., 2000; 47: 425–433.
Labels
Surgery Orthopaedics Trauma surgeryArticle was published in
Perspectives in Surgery
2010 Issue 11
Most read in this issue
- Mucinous Adenocarcinoma of the Appendix – Case Report
- Abdominal Catastrophe – Abdominal Wall Defect Associated with Gastrointestinal Fistula – Strategy of Therapy
- Five-Year Follow up in Patients after Surgery for Clear Cell Renal Carcinoma
- Torsion of the Omentum – An Uncommon Cause of Acute Abdomen