Incidence and Prognostic Significance of Mesorectal Extranodal Tumor Deposits in Patients with Rectal Carcinoma Following Neoadjuvant Therapy
Authors:
D. Umlaufová 1; P. Škapa 2; J. Hoch 1; J. Prausová 3
Authors‘ workplace:
Chirurgická klinika UK 2. LF a FN Motol, Praha, přednosta: prof. MUDr. J. Hoch, CSc.
1; Ústav patologie a molekulární medicíny UK 2. LF a FN Motol, Praha, přednosta: prof. MUDr. R. Kodet, CSc.
2; Radioterapeuticko-onkologické oddělení FN Motol, Praha, primářka: MUDr. J. Prausová, Ph. D., MBA
3
Published in:
Rozhl. Chir., 2009, roč. 88, č. 6, s. 326-329.
Category:
Monothematic special - Original
Overview
Background:
Extranodal mesorectal deposits (ENDs) occure frequently in advanced rectal tumors. It is supposed they are related to a higher incidence of local recurrence and a poor prognosis.
Aim:
To discover both occurrence and impact of ENDs in patients with advanced rectal cancer after neoadjuvant therapy and surgery.
Patients, method: 325 patients meeting following criteria were enrolled: rectal adenocarcinoma, neoadjuvant therapy, anterior or AP rectal resection, complete check up information. Both fresh and archive specimens were examined using standard histopathologic methods.
Results:
ENDs were discovered in 45 from 325 cases. The occurrence of ENDs was significantly higher in increasing stage of tumor (p < 0.001) and in increasing tumor grade (p < 0.001). Positive correlation between number of involved lymph nodes and occurrence of ENDs (p = 0.005) was proved. The 5-year survival rates were border significantly decreased in patients with ENDs (p = 0.052).
Conclusion:
ENDs are the form of metastatic spreading of primary rectal cancer and have negative prognostic impact in 5year survival and increase local recurrence of cancer.
Key word:
rectal cancer – NeoRT/CT – prognosis – extranodal mesorectal involvement
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Surgery Orthopaedics Trauma surgeryArticle was published in
Perspectives in Surgery
2009 Issue 6
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