Significance of C kit and MYB Gene Expression for Diagnosis, Prognosis and Treatment of Adenoid Cystic Carcinoma of the Salivary Glands- the Current Level of Research and Its Application in Clinical Practice
Authors:
M. Brož; I. Stárek; Richard Salzman
Authors‘ workplace:
Klinika otorinolaryngologie a chirurgie hlavy a krku LF UP a Fakultní nemocnice Olomouc
Published in:
Otorinolaryngol Foniatr, 65, 2016, No. 1, pp. 53-57.
Category:
Review Article
Overview
Adenoid cystic carcinoma is the second to third most common malignant tumor of major and predominant neoplasm of minor salivary glands. Along with some other salivary carcinomas, ACC is characterized with difficulties in the prediction of its clinical course. Consequently, new prognostic and predictive molecular biomarkers are being sought. This mainly concerns the identification of genes and related products, responsible for the initiation, progression and metastasizings of tumors. Furthermore, it is supposed that the targeted biological blockade could improve survival curves of high grade salivary tumors associated with dismal prognosis.
This paper reviews the role of C-kit and MYB genes, in recent years intensively studied genetic alterations in diagnosis, prognosis and targeted treatment of adenoid cystic carcinoma of salivary glands.
Keywords:
C kit, MYB, adenoid cystic carcinoma, salivary gland, prognosis, targeted therapy
Sources
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Otorhinolaryngology and Phoniatrics
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