Age as a Risk Factor of Cytotoxicity Caused by Cisplatin

Czech version

Authors: D. Hošnová
Authors‘ workplace: Klinika dětské otorinolaryngologie LF MU a FN Brno, přednosta prof. MUDr. I. Šlapák, CSc.
Published in: Otorinolaryngol Foniatr, 64, 2015, No. 1, pp. 3-7.
Category: Original Article

Overview

Cisplatin is chemotherapy agent, which is used in various types of neoplasia. On of undesirable effects of cisplatin therapy is ototoxicity. The authors followed a group of child patients with the diagnosis of neuroblastoma and osteosarcoma. These two groups differ in diagnosis, mean age of the patients and the cumulative cisplatin dose. All patients were examined by audiology at the beginning and at the end of chemotherapy and a part of the patients also one year after the end of treatment. Age deteriorated during chemotherapy in both groups. The patients with neuroblastoma suffered from a more pronounced deterioration of hearing. Hearing proved to be worse even several years after the end of chemotherapy.

Keywords:
cisplatin, ototoxicity

Sources

1. Adam, Z., Vorlíček, J., Koptíková, J.: Obecná onkologie a podpůrná léčba, Praha, Grada publishing, a.s, 2003.

2. Berglin, C. E., Pierre, P. V., Bramer, T.: Prevention of cisplatin-induced hearing loss by administration of a thiosulfate-containing gel to the middle ear in a guinea pig model. Cancer Chemotherapy and Pharmacology, 68, 2011, s. 1547-1556.

3. Brock, P. R. a spol.: Cisplatin ototoxicity in children: a practical grading system. . Medical and Pediatric Oncology, 19, 1991, sv. 4, s. 295-300.

4. Daldal, A., Odabasi, O., Serbetcioglu, B.: The protective effect of intratympanic dexamethasone on cisplatin-induced ototoxicity in guinea pigs. Otolaryngology- Head and Neck Surgery, 137, 2007, sv. 5, s. 747-752.

5. De Freitas, M. R., et al.: The role of apoptosis in cisplatin-induced ototoxicity in rats. Brazilian Journal of Otorhinolaryngology, 75, 2009, sv. 5, s. 745-752.

6. Elferink, F. a spol.: Interaction of cisplatin and carboplatin with sodium thiosulfate: reaction rates and protein binding. Clinical Chemistry, 32, 1986, sv. 4, s. 641-645.

7. Feghali, J. G., Liu, W., Van De Water, T. R.: L-N-Acetyl-Cysteine Protection against cisplatin-induced auditory neuronal and hair cell toxicity. The Laryngoscope , 111, 2001, sv. 7, s. 1147-1155.

8. Hill, G. W., Morest, D. K., Parham, K.: Cisplatin-induced ototoxicity: effect of intratympanic dexamethasone injections. Otology and Neurotology. 29, 2008, sv. 7, s 1005-1011.

9. Klozar, J. et al.: Speciální otorinolaryngologie, Praha, Galen, 2005.

10. Knight, K. G., Kraemer, D. F., Neuwelt, E. A.: Ototoxicity in children receiving platinum chemotherapy: Underestimating a commonly occurring toxicity that may influence academic and social development. Journal of clinical Oncology, 23, 2005, sv. 34.

11. Moeller, B. J. a spol.: Low early ototoxicity rates for pediatric medulloblastoma patients treated with proton radiotherapy. Radiation Oncology, 6, 2011, sv. 58.

12. Reiter, R. J., Tan, D. X., Korkmaz, A.: Drug-mediated ototoxicity and tinnitus: alleviation with melatonin. Journal of Physiology and Pharmacology, 62, 2011, sv. 2, s. 151-157.

13. Riga, M. G. a spol.: Transtympanic injections of N-acetyl-cysteine for the prevention of cisplatin-induced ototoxicity: A feasible method with promising efficacy. American Journal of Clinical Oncology, 2011.

14. Rybak, L. P. a spol.: Cisplatin ototoxicity and protection: Clinical and experimental studies. The Tohoku Journal of Experimental Medicíně, 219, 2009 , sv. 3, s. 177-186.

15. Sha, S. H.: Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hearing Research, 155, 2001, sv. 1-2, s.1-8.

16. Šlampa, P. a spol.: Ozáření kraniospinální osy u dětí s meduloblastomy v supinační poloze: dlouhodobé výsledky. Česká a Slovenská Neurologie a Neurochirurgie, 70/103, 2007, sv. 3, s. 308-314.

17. Talach, T. a spol.: Ototoxicita indukovaná cisplatinou - klinické sledování a stanovení individuální senzitivity. Otorinolaryngologie a foniatrie, 59, 2010, sv. 4, s. 175-179.

18. Vrabec, P., Lischkeová, B., Skřivan, J., Černý, R., Truc, M.: Rovnovážný systém II – speciální část. Triton, Praha, 2007.