Influence of tobacco smoking on excretion rate of biomarkers of benzene exposure
Authors:
Bajusová I.ihash2ihash4ihash6 1 2 3 1
Authors‘ workplace:
Klinika pracovného lekárstva a klinickej toxikológie LF Univerzity P. J. Šafárika a Univerzitnej nemocnice L. Pasteura, Košice, prednosta doc. MUDr. Ľubomír Legáth, PhD.
1; Ústav verejného zdravotníctva LF Univerzity P. J. Šafárika Košice, prednosta prof. MVDr. Lýdia Čisláková, CSc.
2; Oddelenie pracovného lekárstva a klinickej toxikológie Nemocnice Košice-Šaca, 1. súkromnej nemocnice Košice, primár MUDr. Michal Ihnatko
3
Published in:
Pracov. Lék., 63, 2011, No. 3-4, s. 123-130.
Category:
Original Papers
Overview
Benzene exposure poses a serious risk to human health in the workplace. Benzene has significant hematotoxic effects, causes damage to the central nervous system and immune system, is classified as a Category 1 carcinogen, and a Category 2 mutagen. In this study, we focused on determination and comparison of two biomarkers of benzene exposure. Determination of trans,trans-muconic acid in urine by a HPLC method with UV detection is considered as suitable and acceptable biomonitoring of workplaces, and spectrophotometric determination of phenol in urine. Cigarette smoke contains relatively high concentrations of benzene and becomes a significant additional source of benzene exposure for smokers. The aim of this study was to monitor influence of the length of occupational worker exposure on excretion rate of exposure benzene biomarkers, and to verify a hypothesis whether the amount of selected biomarker excretion is affected by active smoking of exposed workers. The result of a group testing of 105 workers being exposed to benzene was the determination of average concentration values of both excreted biomarkers of benzene exposure with a comparable and short halftime of excretion from the organism. Urine trans,trans-muconic acid concentration was 0.80 (1.34) mg . g-1 creatinine and phenol concentration was 10.64 (12.67) mg . g-1 creatinine. Concentration of trans,trans-muconic acid for workers being exposed to benzene did not exceed a recommended concentration limit of treshold limit value of benzene according to applicable legislation, but it exceeded recommended biological exposure indexes according to the American Conference of Governmental Industrial Hygienists as for samples of biological material taken from exposed workers at the end of the shift. The average phenol content in urine was even at physiologic level. Based on laboratory analyses and statistic data of the group of the exposed workers, no relationship was found between the lenght of occupational exposure and increased selected biomarker excretion. No relationship was confirmed between increased selected biomarker excretion and smoker habits that would affect evaluation of occupational load by inhalation of benzene either.
Key words:
benzene, trans,trans-muconic acid, phenol, smoking
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Labels
Hygiene and epidemiology Hyperbaric medicine Occupational medicineArticle was published in
Occupational Medicine
2011 Issue 3-4
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