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proLékaře.cz / Journals / Journal of Czech Physicians / 2024 - 5

Glucose variability and diabetic microvascular complications

Czech version

Authors: Martin Prázný 1;  Jan Škrha jr. 1;  Jan Šoupal 1;  Eva Horová 1;  Magdaléna Kováčová 2
Published in: Čas. Lék. čes. 2024; 163: 179-184
Category: Review Articles

Overview

Microvascular diabetes complications are linked to inadequate long-term diabetes control, as indicated by glycated haemoglobin (HbA1c) levels. Fluctuations in glucose levels are connected to oxidative stress, endothelial dysfunction, and inflammation, all of which are traditionally linked to the development of vascular damage. While some studies have linked glucose variability to macrovascular disease, its association with microvascular disease is still debated. The major question is whether short-term glucose variability should be regarded as an independent risk factor for microvascular complications in diabetes.

This summary reviews research on glucose variability and its potential connections to diabetic retinopathy, nephropathy, and neuropathy. Current data indicate the need for further research into the parameters of both short-term and long-term glucose variability. These variability parameters may be important for selecting optimal treatment strategies and for estimating the risk of chronic diabetic complications.

Keywords:

glucose variability, glycated hemoglobin HbA1c, microvascular complications, diabetes mellitus

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