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proLékaře.cz / Journals / Journal of Czech Physicians / 2019 - 2

Pathology of cholangiocellular carcinoma

Czech version

Authors: Jan Hrudka 1;  Martin Oliverius 2;  Robert Gürlich 2
Authors‘ workplace: Ústav patologie 3. LF UK a FN Královské Vinohrady, Praha 1;  Chirurgická klinika 3. LF UK a FN Královské Vinohrady, Praha 2
Published in: Čas. Lék. čes. 2019; 158: 57-63
Category: Review Article

Overview

Cholangiocellular carcinoma (CCC) is a malignant tumor harboring a poor prognosis, occurring in the liver, gallbladder and in extra- or intrahepatic biliary ducts. The article reviews the topic concerning CCC from the point of view of a surgical pathologist. The paper deals with classification of CCC into an intrahepatic/peripheral and hilar/extrahepatic subtype with different morphology, molecular features and prognosis; together with classical gross pathology, histopathology and natural history of CCC. Hilar and extrahepatic CCC share some biological characteristics with pancreatic ductal adenocarcinoma.

The review comprises various types of precancerous lesions of biliary tract, summarizes updates in 8th edition of TNM classification and describes the routine issues concerning histopathological diagnostics of CCC, including immunohistochemistry and frozen section methods.

Keywords:

cholangiocellular carcinoma – intrahepatic – hilar – extrahepatic – pathology

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Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist
Epidemiology of gallbladder and bile duct malignancies in the Czech Republic
Molecular pathology of cholangiocellular carcinomas
The role of single-operator cholangioscopy (SpyGlass) in the intraoperative diagnosis of intraductal borders of cholangiocarcinoma proliferation – pilot study
Surgery for cholangiocarcinoma
The current role of radiotherapy and systemic therapy in the multidisciplinary treatment of cholangiocarcinoma
Surveillance of chronic noninfectious diseases
Artificial intelligence and modern information and communication technologies entering medicine
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