Perspectives of male contraception
Authors:
Daniel Driák 1; Ivana Švandová 2
Authors‘ workplace:
Gynekologicko-porodnická klinika 1. LF UK a Nemocnice Na Bulovce, Praha
1; Katedra fyziologie, Přírodovědecká fakulta UK, Praha
2
Published in:
Čas. Lék. čes. 2013; 152: 263-266
Category:
Review Article
Overview
The principle of suppressive methods of male contraception is to repress the sperm production and its functions by hormonal, chemical, physical, immunological or other ways. Of hormonal methods, the most perspective seems to be the steroid blockade of spermatogenesis. In horizon of ten years, it might be expected that the first male hormonal contraception will be available in form of injections or implants, however the „male pill“ will not become a reality in the near future. Blockade of calcium channels by means of pharmacological inhibitors seems to be another promising mechanism of sperm functions inhibition. Based on the results of research of last two decades, the method of „reversible vasectomy“ might be accessible, too.
Keywords:
male contraception – suppression of spermiogenesis – calcium channels blockade – reversible vasectomy
Sources
1. Zvěřina J. Sexuologie (nejen) pro lékaře. Brno: Akademické nakladatelství CERM 2003.
2. Anderson RA. Male steroidal contraception. Eur J Contracept Reprod Health Care 2004; 9(Suppl 1): 27.
3. Lishko PV, et al. The control of male fertility by spermatozoan ion channels. Annu Rev Physiol 2012; 74: 453–475.
4. Shukla KK, et al. Ion channels in sperm physiology and male fertility and infertility. J Androl 2012; 33(5): 777-788.
5. Zheng LP, et al. Sperm-specific ion channels: targets holding the most potential for male conctraceptives in development. Contraception 2013; 88(4): 485–491.
6. WHO. Task force on methods for the regulation of male fertility. Lancet 1990; 336: 955–959.
7. Kamischke A, et al. Progress towards hormonal male contraception. Trends Pharmacol Sci 2004; 25: 49–57.
8. Weiss P, et al. Sexuologie. Praha: Grada Publishing 2010.
9. Pasqualotto FF, et al. Trends in male contraception. Rev Hosp Clin Fac Med Sao Paulo 2003; 58(5): 275–283.
10. Meriggiola MC, et al. A review of androgen-progestin regimens for male contraception. J Androl 2003; 24: 466–483.
11. Lohiya NK, et al. Perspectives of contraceptive choices for men. Indian J Exp Biol 2005; 43(11): 1042–1047.
12. Rajalakshmi M, et al. Evaluation of the ability of levonorgetsrel butanoate alon, or in combination with testosterone buciclate, to supress spermatogenesis in the bonnet monkey (Macaca radiata). Int J Androl 2000; 23(2): 95–105.
13. Wang C, et al. Male hormonal contraception. Am J Obstet Gynecol 2004; 190: S60–68.
14. Kanwar U, et al. The effect of nifedipine, a calcium channel blocker, on human spermatozoal functions. Contraception 1993; 48: 453–470.
15. Benoff S, et al. Fertilization potential in vitro is correlated with head-specific mannose-ligand receptor expression, acrosome status and membrane cholesterol content. Hum Reprod 1993; 8: 2155–2166.
16. Driák D, et al. Blokáda vápníkových kanálů – perspektiva mužské antikoncepce? Čes Gynek 2013; 78(2): 216–220.
17. Naz RK, et al. Recent advances in contraceptive vaccine development: a mini-review. Hum Reprod 2005; 20: 3271–3283.
18. Chaudhury K, et al. Studies on the membrane integrity of human sperm treated with a new injectable male contraceptive. Hum Reprod 2004; 9(8): 1826–1830.
19. Guha SK, et al. Phase II clinical trial of a vas deferens injectable contraceptive for the male. Contraception 1997; 56(4): 245–250.
20. Mishra PK, et al. Status of spermatogenesis and sperm parameters in langur monkeys following long-term vas occlusion with styrene maleic anhydride. J Androl 2003; 24(4): 501–509.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
Journal of Czech Physicians
Most read in this issue
- Perspectives of male contraception
- Deferred breast reconstruction – soul surgery?
- First experience with the personalised dependence degree assessment for the purposes of care allowance
- Health and tradecorporations