Cancer microenvironment affects biological properties of tumor cells – tumor as an embryologic problem?
Authors:
Karel Smetana ml. 1,2; Barbora Dvořánková 1,2; Lukáš Lacina 1,2,3; Eliška Krejčí 1; Miloš Grim 1,2
Authors‘ workplace:
Univerzita Karlova v Praze, 1. lékařská fakulta, Anatomický ústav
1; Univerzita Karlova v Praze, 2. lékařská fakulta, Centrum buněčné terapie a tkáňových náhrad
2; Univerzita Karlova v Praze, 1. lékařská fakulta, Klinika dermatovenerologie
3
Published in:
Čas. Lék. čes. 2010; 149: 572-575
Category:
Review Article
Overview
Mutual epithelial-mesenchymal interaction represents a fundamental control mechanism during the development of organs and tissues. This review article demonstrates the importance of such interaction for tumor formation where it influences the biological properties of cancer stem cell and tumor itself. The teratoma and melanoma are employed as examples to demonstrate the influence of embryonic microenvironment on the biological properties of tumor, mainly on its potential to metastasize. The manipulation of cancer microenvironment represents the perspective therapeutic tool for cancer treatment in future.
Key words:
cancer microenvironment, cancer-associated fibroblast, squamous cell carcinoma, neural crest, melanoma.
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Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
Journal of Czech Physicians
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