Metabolic Effects of the Endocannabinoid System
Authors:
T. Kvasnička
Authors‘ workplace:
III. interní klinika – klinika endokrinologie a metabolizmu 1. LF UK a VFN, Praha
Published in:
Čas. Lék. čes. 2008; 147: 81-84
Category:
Review Article
Overview
The endocannabinoid system (ECS) is an endogenous signalling system that plays an important role in the regulation of energy homeostasis and lipid and glucose metabolism-all of which can influence cardiometabolic risk. Endocannabinoids are involved in the appetite and body weight regulation. Central or peripheral stimulation of ECS favours metabolic processes that lead to weight gain, lipogenesis, insulin resistance, dyslipidemia, and impaired glucose homeostasis. ECS is tonically overactive in obese individuals. ECS appears to be a promising novel mechanistic pathway that modulates important aspects of the cardiovascular and metabolic function.
Key words:
endocannabinoids, anadamid, receptor: CB1, CB2, obesity, cardiometabolic risk.
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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
Journal of Czech Physicians
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