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Urocanic Acid and its Role in Photoimmunomodulation


Authors: L. Malina
Authors‘ workplace: Katedra dermatovenerologie IPVZ, Praha
Published in: Čas. Lék. čes. 2003; : 470-473
Category:

Overview

Urocanic acid (UCA) is a metabolite of the amino acid histidine. It represents an important chromatophore inepidermis, which can absorb ultraviolet rays in UVB and UVA region and sequentially convert it from trans- tocis-isomer. Cis-isomer is not further degraded; it accumulates in the skin and is excreted with sweat and in sheddingkeratin scales.UCA has several important functions, the regulation of the homeostasis of the acidic cutaneous surface,the terminal differentiation of epidermal cells and namely the immunomodulatory role. As and immunomodulatorUCA can suppress contact allergic reaction and the delayed hypersensitivity of the organism. It can affect reactionsmediated by Th-lymphocytes, cytokine system, Langerhans cells, and by some neuropeptides. UCA is related to thedevelopment of non-pigmented skin tumors (basaliomas) and indirectly also to pigmented tumors. Cis-UCA caninhibit both the local and systemic resistance to infectious agents. In the immunomodulation some adductivecompounds with another important cutaneous chromatophore DNA can participate.

Key words:
Urocanic acid, immunomodulation, photoimmunosupression, ultraviolet light, UVB, UVA, photobiology.

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Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

Article was published in

Journal of Czech Physicians


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