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Hepcidin – The Peptide Regulating the Body Amount and Distribution of Iron in Health andDisease


Authors: M. Vokurka;  E. Nečas
Authors‘ workplace: Ústav patologické fyziologie 1. LF UK, Praha
Published in: Čas. Lék. čes. 2003; : 465-469
Category:

Overview

Iron is an essential element and its amount and balance must be precisely regulated. Iron intestinal absorption isessential for the iron balance; however, the precise mechanism of its regulation remains unknown. Antimicrobialpeptide hepcidin, produced in the liver, is considered as a key regulator of iron absorption and kinetics in the organism.Its expression increases in response to the iron overload. Hepcidin decreases iron absorption in the duodenum andcauses its sequestration in macrophages. Apart from the iron, inflammation increases hepcidin expression in theliver, and hepcidin is considered to be acute phase protein. Hepcidin is not only the physiological regulator of ironkinetics but is supposed to be a part of the pathogenetic mechanism of anaemia accompanying chronic diseases andits relationship to the hereditary hemochromatosis is also studied.

Key words:
hepcidin, iron, hemochromatosis, anaemia, inflammation, acute phase proteins.

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Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

Article was published in

Journal of Czech Physicians


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