Parameters of BoneMetabolism in Patients with Renal Function Impairmentsof Various Degrees

Overview

Background.
Patientswith renal failure frequently have their calciumand phosphate metabolismseriously disrupted.It may result in a skeletal malady – the renal osteopathy. Late forms of this syndrome are difficult to cure. The aimof this comparative study is to follow the relation between parameters of the bone metabolism (calcitriol, calcidiol,parathormone, calcitonin, osteocalcin, Pi, Ca – total or ionised, and others) and the degree of deterioration of thekidney function.Methods and Results. Three groups of patientswere included into the study: A – hemodialyzed patients with chronicrenal failure (Ccreat=0.07±0.02 ml/s, n=21, age 71.0±10.6 years); B – not dialyzed patients with decreased renalfunction (Ccreat=0.33±0.05ml/s, n=19, age 65.0±9.6 years); C– patientswith normal renal function (Ccreat=1.45±0.12ml/s, n=16, age 85.2±4.7 years). Calcidiol concentration [µg/l] did not differ in individual groups (A:11.3±4.7,B:10.7±8.2, C:11.7±5.7, reference limits RM:8.9–46.7). In contrast, calcitriol concentration [ng/l] was statisticallydifferent in all studied groups (A:1.7±2.8, B:17.6±12.4, C:30.6±9.1, p

Key words:
renal osteopathy, chronic renal failure, bone markers, calcitriol, calcidiol, parathormone, metabolicacidosis.