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Laboratory Markers of EndothelialInvolvement in Rheumatic Diseases with Vasculitis in Childhood


Authors: P. Doležalová;  P. Telekešová;  D. Němcová;  J. Bělorová;  J. Kvasnička;  J. Hoza
Authors‘ workplace: Klinika dětského a dorostového lékařství 1. LF UK a VFN, Praha Oddělení klinické hematologie 1. LF UK a VFN, Praha
Published in: Čas. Lék. čes. 2003; : 615-619
Category:

Overview

Backround.
Endothelial activation is an important etiopathogenetic factor in a group of disorders characterised byprimary or secondary vasculitis. The aim of our study was to determine blood concentrations of von Willebrandfactor (vWF), vypuštěno soluble intercellular adhesion molecule-1 (ICAM-1) and E-selectin (E-sel) in children withvarious rheumatic diseases and in paediatric controls and to correlate them with clinical and laboratory variables.Methods and Results. Total of 28 healthy children (ZD) and 48 patients were evaluated: 6 with systemic lupuserythematosus (SLE), 7 with other diffuse connective tissue diseases (SSD), 11 with Henoch-Schönlein purpura(HSP), 14 with oligoarticular juvenile idiopathic arthritis (JIA) and 10 febrile controls (FC). Erythrocyte sedimentationrate (ESR), C-reactive protein (CRP) and full blood count were recorded. ICAM-1, E-sel and vWF concentrationswere measured by sandwich ELISA kits. In SLE patients’ concentrations of vWF and ICAM-1 weresignificantly higher than in healthy (p

Key words:
intercellular adhesion molecule-1, E-selectin, von Willebrand factor, rheumatic diseases,children.

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Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

Article was published in

Journal of Czech Physicians


2003 Issue 10

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