Adjuvant Therapy of the Renal Carcinoma

Overview

A treatment approach in a group of 1498 patients with renal cell carcinoma (RCC) was studied. Out of these, 86patients had the primarily generalised form. For the therapy of primary advanced metastasis, the treatment strategywas changed from conservative to an active approach. Such approach is based on the removal of 75 % of the tumormass, the patient should be in good conditions with no metastases in CNS, bone and liver, and the primary tumorshould not be a sarcoma. The new treatment strategy of patients with advanced RCC combines surgery andchemoimmunotherapy. 47 patients from the studied group were treated with combined INF alpha+IL-2+5FU+isotretinoinusing the Atzpodien scheme. The toxicity wasminimal and only in six patients the treatment was interruptedbecause of the disease progression. Results of this treatment strategy are encouraging, however, further randomisedtrials are recommended.

Key words:
renal cell carcinoma, surgery, chemotherapy, immunotherapy.