Hereditary hemorrhagic telangiectasia (Osler‑Weber‑Rendu syndrome) – Part II. Pharmacological therapy and international guidelines for the therapy 2020
Authors:
Zdeněk Adam 1; Dagmar Brančiková 1; Gabriela Romanová 2; Luděk Pour 1; Marta Krejčí 1; Jiří König 3; Tomáš Nebeský 4; Zuzana Adamová 5; Martin Štork 1; Martin Krejčí 1; Sabina Ševčíková 4; Michal Eid 1; Viera Sandecká 1; Zdeněk Král 1
Authors‘ workplace:
Interní hematologická a onkologická klinika LF MU a FN Brno
1; Oddělení klinické hematologie FN Brno
2; Oddělní krční, nosní, ušní FN Brno
3; Klinika radiologie a nukleární medicíny – FN Brno
4; Ústav patologické fyziologie LF MU a FN Brno
5; Chirurgické oddělení nemocnice Vsetín
6
Published in:
Vnitř Lék 2021; 67(7): 419-424
Category:
Review Articles
Overview
Hereditary hemorrhagic telangiectasia also known as Osler-Weber-Rendu syndrome, is an disorder that causes abnormal blood vessel formation with bleeding. Inhibition of angiogenesis amelioretes bleeding complication. Anti-angiogenic agents such as bevacizumab, aflibercept, thalidomid, lenadomid and other new anti-angiogenic thyrosinkinase inhibitors, as well as sirolimus and takrolimus have emerged as a promising systemic or local therapy in reducing bleeding complications but are not curative. Other pharmacological agents include iron supplementation, antifibrinolytics and hormonal treatment. This review concentrates on new anti-agioproliferative drugs with effect in HHT- discusses the new biology of HHT, management issues that face the practising hematologist, and considerations of future directions in HHT treatment.
Keywords:
sirolimus – bevacizumab – aflibercept – thalidomid – tacrolimus – hereditary hemorrhagic telangiectasia – lenadomid anti‑angiogenic thyrosinkinase inhibitors
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Další literatura u autora a na www.casopisvnitrnilekarstvi.cz
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Diabetology Endocrinology Internal medicineArticle was published in
Internal Medicine
2021 Issue 7
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