Lung diseases and autoimmune hemolytic anemia associted with IgG4 disease

Czech version

Authors: Martina Doubková ¹; Radoslav Matěj ²; Zita Chovancová ³; Michael Doubek ^4,5
Authors‘ workplace: Klinika nemocí plicních a tuberkulózy LF MU a FN Brno, pracoviště Bohunice ¹; Ústav patologie a molekulární medicíny 3. LF UK a Thomayerovy nemocnice, Praha ²; Ústav klinické imunologie a alergologie LF MU a FN u sv. Anny Brno ³; Interní hematologická a onkologická klinika LF MU a FN Brno pracoviště Bohunice ⁴; Středoevropský technologický institut MU Brno ⁵
Published in: Vnitř Lék 2020; 66(4): 47-52
Category:

Overview

IgG4 related disease (IgG4-RD) is a rare and relatively new group of systemic inflammatory diseases characterized by inflammatory, fibrotic or sclerotic involvement of one or more organs accompanied by increased IgG4plasma cells tissue infiltration andusually elevated serum IgG4(IgG4 > 1.35g/l, normal range 0.08–1.40 g/l) level. Histopathological findings are crucial for the diagnostics of this disease. The authors present a case report of a patient with IgG4 associated disease manifested by a rare combination of autoimmune hemolytic anemia and pulmonary involvement.

Keywords:

autoimmune haemolytic anemia – IgG4 associated disease – interstitial lung disease

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