#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Non-celiac gluten/wheat sensitivity: still more questions than answers


Authors: Iva Hoffmanová
Authors‘ workplace: II. interní klinika 3. LF UK a FN Královské Vinohrady, Praha
Published in: Vnitř Lék 2019; 65(1): 19-23
Category:

Overview

Non-celiac gluten/wheat sensitivity (NCG/WS) is a syndrome characterized by intestinal and extra-intestinal sym­ptoms elicited by gluten/wheat ingestion in the persons, who are not affected by celiac disease and wheat allergy. Due to the lack of established biomarkers, the diagnosis of NCG/WS is based on the clinical picture, and it is necessary to validate it in well-defined double-blind, placebo-controlled challenge (The Salerno Experts´ Criteria). In the article is discussed a current knowledge of NCG/WS in terms of pathogenesis, diagnosis and treatment.

Key words:

gluten – gluten-related disorders – non-celiac gluten/wheat sensitivity – wheat


Sources
  1. Hoffmanová I, Sánchez D. Non-celiac gluten sensitivity. Vnitř Lék 2015; 61(3): 219–227.
  2. Sapone A, Bai JC, Ciacci C et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med 2012; 10: 13. Dostupné z DOI: <http://dx.doi.org/10.1186/1741–7015–10–13>.
  3. Junker Y, Zeissig S, Kim S et al. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. J Exp Med. 2012; 209(13): 2395–2408. Dostupné z DOI: <http://dx.doi.org/10.1084/jem.20102660>.
  4. Schuppan D, Pickert G, Ashfaq-Khan M et al. Non-celiac wheat sensitivity: differential diagnosis, triggers and implications. Best Pract Res Clin Gastroenterol 2015; 29(3):469–476. Dostupné z DOI: <http://dx.doi.org/10.1016/j.bpg.2015.04.002>.
  5. Gibson PR, Shepherd SJ. Food choice as a key management strategy for functional gastrointestinal symptoms. Am J Gastroenterol 2012; 107(5): 657–666; quiz 667. Dostupné z DOI: <http://dx.doi.org/10.1038/ajg.2012.49>.
  6. Biesiekierski JR, Peters SL, Newnham ED et al. No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology 2013; 145(2): 320–328. Dostupné z DOI: <http://dx.doi.org/10.1053/j.gastro.2013.04.051>.
  7. Catassi C, Elli L, Bonaz B et al. Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts‘ Criteria. Nutrients 2015; 7(6): 4966–4977. Dostupné z DOI: <http://dx.doi.org/10.3390/nu7064966>.
  8. Choung RS, Unalp-Arida A, Ruhl CE et al. Less Hidden Celiac Disease But Increased Gluten Avoidance Without a Diagnosis in the United States: Findings From the National Health and Nutrition Examination Surveys From 2009 to 2014. Mayo Clin Proc 2016. pii: S0025–6196(16)30634–6. Dostupné z DOI: <http://dx.doi.org/10.1016/j.mayocp.2016.10.012>.
  9. Schnedl WJ, Lackner S, Enko D et al. Non-celiac gluten sensitivity: people without celiac disease avoiding gluten-is it due to histamine intolerance? Inflamm Res 2018; 67(4):279–284. Dostupné z DOI: <http://dx.doi.org/10.1007/s00011–017–1117–4>.
  10. Fasano A, Sapone A, Zevallos V et al. Nonceliac gluten sensitivity. Gastroenterology 2015; 148(6): 1195–1204. Dostupné z DOI: <http://dx.doi.org/10.1053/j.gastro.2014.12.049>.
  11. de Lorgeril M, Salen P. Gluten and wheat intolerance today: are modern wheat strains involved? Int J Food Sci Nutr 2014; 65(5): 577–581. Dostupné z DOI: <http://dx.doi.org/10.3109/09637486.2014.886185>.
  12. Valerii MC, Ricci C, Spisni E et al. Responses of peripheral blood mononucleated cells from non-celiac gluten sensitive patients to various cereal sources. Food Chem 2015; 176: 167–174. Dostupné z DOI: <http://dx.doi.org/10.1016/j.foodchem.2014.12.061>.
  13. Alvisi P, Fazio L de, Valerii MC et al. Responses of blood mononucleated cells and clinical outcome of non-celiac gluten sensitive pediatric patients to various cereal sources: a pilot study. Int J Food Sci Nutr 2017; 68(8): 1005–1012. Dostupné z DOI: <http://dx.doi.org/10.1080/09637486.2017.1315058>.
  14. Kasarda DD. Can an increase in celiac disease be attributed to an increase in the gluten content of wheat as a consequence of wheat breeding? J Agric Food Chem 2013; 61(6): 1155–1159. Dostupné z DOI: <http://dx.doi.org/10.1021/jf305122s>.
  15. Kucek LK, VeenstraLD, Amnuaycheewa P et al. A Grounded Guide to Gluten: How Modern Genotypes and Processing Impact Wheat Sensitivity. Comprehensive Rev Food Sci Food Saf 2015; 14(3): 285–302. Dostupné z DOI: <https://doi.org/10.1111/1541–4337.12129>.
  16. Volta U, Caio G, Karunaratne TB et al. Non-coeliac gluten/wheat sensitivity: advances in knowledge and relevant questions. Expert Rev Gastroenterol Hepatol 2017; 11(1): 9–18. Dostupné z DOI: <http://dx.doi.org/10.1080/17474124.2017.1260003
  17. Lionetti E, Pulvirenti A, Vallorani M et al. Re-challenge Studies in Non-celiac Gluten Sensitivity: A Systematic Review and Meta-Analysis. Front Physiol 2017; 8: 621.Dostupné z DOI: <http://dx.doi.org/10.3389/fphys.2017.00621>.
  18. Hollon J, Puppa EL, Greenwald B et al. Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity. Nutrients 2015; 7(3): 1565–1576. Dostupné z DOI: <http://dx.doi.org/10.3390/nu7031565>.
  19. Uhde M, Ajamian M, Caio G et al. Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease. Gut 2016; 65(12): 1930–1937. Dostupné z DOI: <http://dx.doi.org/10.1136/gutjnl-2016–311964>.
  20. Volta U, Caio G, Tovoli F et al. Non-celiac gluten sensitivity: questions still to be answered despite increasing awareness. Cell Mol Immunol 2013; 10(5): 383–392. Dostupné z DOI: <http://dx.doi.org/10.1038/cmi.2013.28>.
  21. Sapone A, Lammers KM, Casolaro V et al. Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Med 2011; 9: 23. Dostupné z DOI: <http://dx.doi.org/10.1186/1741–7015–9-23>.
  22. Vazquez-Roque MI, Camilleri M, Smyrk T et al. A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function. Gastroenterology 2013; 144(5): 903–911. Dostupné z DOI: <http://dx.doi.org/10.1053/j.gastro.2013.01.049>.
  23. Holmes G. Non coeliac gluten sensitivity. Gastroenterol Hepatol Bed Bench 2013; 6(3): 115–119.
  24. Brottveit M, Beitnes AR, Tollefsen S et al. Mucosal cytokine response after short-term gluten challenge in celiac disease and non-celiac gluten sensitivity. Am J Gastroenterol 2013; 108(5):842–850. Dostupné z DOI: <http://dx.doi.org/10.1038/ajg.2013.91>.
  25. Di Sabatino A, Giuffrida P, Fornasa G et al. Innate and adaptive immunity in self-reported nonceliac gluten sensitivity versus celiac disease. Dig Liver Dis 2016; 48(7): 745–752. Dostupné z DOI: <http://dx.doi.org/10.1016/j.dld.2016.03.024>.
  26. Gibson PR, Varney J, Malakar S et al. Food components and irritable bowel syndrome. Gastroenterology 2015; 148(6): 1158–1174. Dostupné z DOI: <http://dx.doi.org/10.1053/j.gastro.2015.02.005>.
  27. Bohn L, Storsrud S, Liljebo T et al. Diet low in FODMAPs reduces symptoms of irritable bowel syndrome as well as traditional dietary advice: a randomized controlled trial. Gastroenterology 2015; 149(6): 1399–1407. Dostupné z DOI: <http://dx.doi.org/10.1053/j.gastro.2015.07.054>.
  28. Carroccio A, Mansueto P, Iacono G et al. Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity. Am J Gastroenterol 2012; 107(12): 1898–1906; quiz 1907. Dostupné z DOI: <http://dx.doi.org/10.1038/ajg.2012.236>.
  29. Biesiekierski JR, Newnham ED, Irving PM et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am J Gastroenterol 2011; 106(3): 508–514; quiz 515. Dostupné z DOI: <http://dx.doi.org/10.1038/ajg.2010.487>.
  30. Volta U, Bardella MT, Calabro A et al. An Italian prospective multicenter survey on patients suspected of having non-celiac gluten sensitivity. BMC Med 2014; 12: 85. Dostupné z DOI: <http://dx.doi.org/10.1186/1741–7015–12–85>.
  31. Kabbani TA, Vanga RR, Leffler DA et al. Celiac disease or non-celiac gluten sensitivity? An approach to clinical differential diagnosis. Am J Gastroenterol 2014; 109(5): 741–746; quiz 747. Dostupné z DOI: <http://dx.doi.org/10.1038/ajg.2014.41>.
  32. Carroccio A, D‘Alcamo A, Cavataio F et al. High Proportions of People With Nonceliac Wheat Sensitivity Have Autoimmune Disease or Antinuclear Antibodies. Gastroenterology 2015; 149(3): 596–603. Dostupné z DOI: <http://dx.doi.org/10.1053/j.gastro.2015.05.040>.
  33. Paul SP, Hoghton M, Sandhu B. Limited role of HLA DQ2/8 genotyping in diagnosing coeliac disease. Scott Med J 2017; 62(1): 25–27. Dostupné z DOI: <http://dx.doi.org/10.1177/0036933016689008>.
  34. Catassi G, Lionetti E, Gatti S et al. The Low FODMAP Diet: Many Question Marks for a Catchy Acronym. Nutrients 2017; 9(3). pii: E292. Dostupné z DOI: <http://dx.doi.org/10.3390/nu9030292>.
  35. Barrett JS. How to institute the low-FODMAP diet. J Gastroenterol Hepatol 2017;32(Suppl 1): 8–10. Dostupné z DOI: <http://dx.doi.org/10.1111/jgh.13686>.
Labels
Diabetology Endocrinology Internal medicine
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#