#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Hypergastrinaemia without detection of gastrinoma


Authors: Ľ. Cibičková 1,2;  J. Janková 3;  Ľ. Víchová 4
Authors‘ workplace: Interní oddělení Nemocnice Hranice, a. s., Hranice, prim. MUDr. Zbyněk Jelínek 1;  Ústav patologické fyziologie Lékařské fakulty UP Olomouc, přednosta prof. MUDr. Jaroslav Veselý, CSc. 2;  Ústav klinické a molekulární patologie Lékařské fakulty UP a FN Olomouc, přednosta prof. MUDr. Zdeněk Kolář, CSc. 3;  Praktická lékařka pro dorost a dospělé Hranice 4
Published in: Vnitř Lék 2012; 58(4): 322-324
Category: Case Reports

Overview

We present a case-report of a woman with persisting gastric ulcers, who had elevated gastrin blood levels. First of all, a rare cause of hypergastrinaemia was excluded – a gastrinoma. It was not found despite of extensive investigation. Ulcers were repetitively biopted and transition of high grade dysplasia to adenocarcinoma was detected. Gastrin levels normalised after surgical antrectomia. Afterwards pernicious anaemia was diagnosed as the underlining cause of hypergastrinaemia.

Key words:
gastrin – gastrinoma – pernicious anaemia


Sources

1. Murugesan SVM, Varro A, Pritchard DM. Review article: strategies to determine whether hypergastrinaemia is due to Zollinger-Ellison syndrome rather than a more common benign cause. Aliment Pharmacol Ther 2009; 29: 1055–1068.

2. Arnold R. Diagnosis and differential diagnosis of hypergastrinemia. Wien Klin Wochenschr 2007; 119: 564–569.

3. Zamrazil V. Neuroendokrinní systém a jeho význam. Neuroendokrinní tumory. Postgraduální medicína 2010; 12: 620–626.

4. Qvigstad G, Qvigstad T, Westre B et al. Neuroendocrine differentiation in gastric adenocarcinomas associated with severe hypergastrinemia and/or pernicious anemia. APMIS 2002; 110: 132–139.

5. Chambers AJ, Pasieka JL. Gastrinoma. Cancer Treat Res 2010; 153: 213–233.

Labels
Diabetology Endocrinology Internal medicine
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#