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Diabetes mellitus and dementia


Authors: I. Tůma
Authors‘ workplace: Psychiatrická klinika Lékařské fakulty UK a FN Hradec Králové, přednosta prof. MUDr. Jan Libiger, CSc.
Published in: Vnitř Lék 2012; 58(4): 305-308
Category: Reviews

Overview

Patients with diabetes are at increased risk of developing cognitive impairment in comparison with the general population. Diabetes mellitus increases the risk of dementia (vascular and/or neurodegenerative). Diabetes accelerates the progression from mild cognitive impairment to dementia. It has been estimated that type 2 diabetes or impairment of glucose metabolism might be present in up to 80% of patients with Alzheimer disease. The cognitive dysfunction is associated with poorer ability in diabetes self-care and decreased adherence to antidiabetic treatment.

Key words:
diabetes mellitus – cognition – dementia – Alzheimer disease


Sources

1. Akisaki T, Sakurai T, Takata T et al. Cognitive dysfunction associates with white matter hyperintensities and subcortical atrophy on magnetic resonance imaging of the elderly diabetes mellitus Japanese elderly diabetes intervention trial (J-EDIT). Diabetes Metab Res Rev 2006; 22: 376–384.

2. Akomolafe A, Beiser A, Meigs JB et al. Diabetes mellitus and risk of developing Alzheimer dinase: results from the Framingham Study. Arch Neurol 2006; 63: 1551–1555.

3. Arvanitakis Z, Wilson RS, Bienias JL et al. Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch Neurol 2004; 61: 661–666.

4. Arvanitakis Z, Schneider JA, Wilson RS et al. Diabetes is related to cerebral infarction but not to AD pathology in older persons. Neurology 2006; 67: 1960–1965.

5. Beeri MS, Silverman JM, Davis KL et al. Type 2 diabetes is negatively associated with Alzheimer’s disease neuropathology. J Gerontol A Biol Sci Med Sci 2005; 60: 471–475.

6. Beeri MS, Schmeidler J, Silverman JM et al. Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology. Neurology 2008; 71: 750–757.

7. Cukierman T, Gerstein HC, Williamson JD. Cognitive decline and dementia in diabetes – systematic overview of prospective observational studies. Diabetologia 2005; 48: 2460–2469.

8. de la Monte SM, Tong M, Lester-Coll N et al. Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer’s disease. J Alzheimers Dis 2006; 10: 89–109.

9. de la Monte SM. Insulin resistance and Alzheimer’s disease. BMB Rep 2009; 42: 475–481.

10. D’Ercole AJ, Ye P, Calikoglu AS et al. The role of the insulin-like growth factors in the central nervous system. Mol Neurobiol 1996; 13: 227–255.

11. Gustavsson A, Svensson M, Jacobi F et al. CDBE2010Study Group. Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 2011; 21: 718–779.

12. Heitner J, Dickson D. Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects. A retrospective postmortem immunocytochemical and histofluorescent study. Neurology 1997; 49: 1306–1311.

13. Janson J, Laedtke T, Parisi JE et al. Increased risk of type 2 diabetes in Alzheimer disease. Diabetes 2004; 53: 474–481.

14. Kumari M, Marmot M. Diabetes and cognitive function in a middle-aged cohort: findings from the Whitehall II study. Neurology 2005; 65: 1597–1603.

15. Leibson CL, Rocca WA, Hanson VA et al. The risk of dementia among persons with diabetes mellitus: a population-based cohort study. Ann NY Acad Sci 1997; 826: 422–427.

16. Ott A, Stolk RP, van Harskamp F et al. Diabetes mellitus and the risk of dementia: The Rotterdam Study. Neurology 1999; 53: 1937–1942.

17. Rivera EJ, Goldin A, Fulmer N et al. Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzhei­mer’s disease: link to brain reductions in acetylcholine. J Alzheimers Dis 2005; 8: 247–268.

18. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 2010; 87: 4–14.

19. Schrijvers EM, Witteman JC, Sijbrands EJ et al. Insulin metabolism and the risk of Alz­heimer disease: the Rotterdam Study. Neurology 2010; 75: 1982–1987.

20. Schmidt R, Launer LJ, Nilsson LG et al. CASCADE Consortium. Magnetic resonance imaging of the brain in diabetes: the Cardiovascular Determinants of Dementia (CASCADE) Study. Diabetes 2004; 53: 687–692.

21. Steen E, Terry BM, Rivera EJ et al. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer’s disease – is this type 3 diabetes? J Alzheimers Dis 2005; 7: 63–80.

22. Tůma I. Diabetes mellitus a kognitivní poruchy. Vnitř Lék 2007; 53: 486–488.

23. Weber P. Diabetes mellitus – specifika a komplikace ve stáří. Interní Med 2008; 10: 456–460.

24. Whitmer RA, Karter AJ, Yaffe K et al. Hypoglycemic Episodes and Risk of Dementia in Older Patients With Type 2 Diabetes Mellitus. JAMA 2009; 301: 1565–1572.

25. Xu W, Qiu C, Gatz M et al. Mid- and late-life diabetes in relation to the risk of dementia: a population-based twin study. Diabetes 2009; 58: 71–77.

26. Xu WL, von Strauss E, Qiu CX et al. Uncontrolled diabetes increases the risk of Alzheimer’s disease: a population-based cohort study. Diabetologia 2009; 52: 1031–1039.

27. Xu W, Caracciolo B, Wang HX et al. Accelerated progression from mild cognitive impairment to dementia in people with diabetes. Diabetes 2010; 59: 2928–2935.

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Diabetology Endocrinology Internal medicine
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