Statin pharmacokinetics
Authors:
J. A. Hubáček 1,2; V. Adámková 1; K. Zídková 3; R. Češka 3; L. Zlatohlávek 3; T. Štulc 3; A. Hořínek 3; M. Vráblík 3
Authors‘ workplace:
Institut klinické a experimentální medicíny Praha, ředitel doc. MUDr. Jan Malý, CSc.
1; Centrum výzkumu chorob srdce a cév IKKEM Praha, ředitel prof. MUDr. Bohuslav Ošťádal, DrSc.
2; III. interní klinika 1. lékařské fakulty UK a VFN Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA
3
Published in:
Vnitř Lék 2008; 54(1): 62-67
Category:
Review
Overview
Reducing high levels of plasmatic lipoids (LDL-cholesterol and triglycerides) is one of the most important steps in the prevention and treatment of cardiovascular diseases. In the majority of cases, treatment based on lifestyle changes (changes in dietary habits, more physical activity) is not sufficient and pharmacotherapy becomes necessary. Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are a well tolerated first-choice drug in patients with dyslipidemia. However, great variability of statin effects has been observed in different patients on the same therapy, and the cause clearly resides in different genetic characteristics of each individual, influencing the effect of therapy. The influence of different genetic variants has been described, but the control of response to hypolipidemic therapy is most likely subject to polygenic control. The analysis of multiple gene combinations may help detect the "hyper-" and "hypo-" responders, i.e. individuals with a good response to treatment (allowing for starting with a lower dose of the drug), and those with an insufficient response to treatment (in whom statin shall not be the drug of first choice), or it may help detect the patients who are more likely to develop severe adverse events. Studies with different designs describe that for instance genes (and their variants) for cytochromes, apolipoprotein E and A1 and cholesterol 7α-hydroxylase may be important genetic determinants of the effect of pharmacological treatment of dyslipidemia and play a role in the individualisation of treatment.
Keywords:
statins – dyslipidemia – gene variability – pharmacogenetics
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