Nuclear receptors PPARα

Czech version

Authors: V. Soška
Authors‘ workplace: Centrum pro diagnostiku a léčbu dyslipidemií, Oddělení klinického komplementu FN u sv. Anny, Brno, přednosta doc. MUDr. Vladimír Soška, CSc.
Published in: Vnitř Lék 2006; 52(6): 628-631
Category: Reviews

Overview

Mechanism of the fibrates action is mediated by nuclear PPARα receptors (Peroxisome Proliferator-Activated Receptor). These receptors regulate a number of genes that are involved both in lipids and lipoproteins metabolism and other mediators (e.g. inflammatory mediatores). Due to PPARα activation by fibrates, triglycerides and small dense LDL concentration is decreased, HDL cholesterol is increased and both inflammation and prothrombotic status are reduced. These effects are very important in patients with metabolic syndrom.

Key words:
nuclear receptors PPARα - fibrates - statins - metabolic syndrom

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