Biological treatment of rheumatic diseases

Czech version

Authors: L. Procházková; J. Böhmová; M. Souček
Authors‘ workplace: II. interní klinika Lékařské fakulty MU a FN u sv. Anny, Brno, přednosta doc. MUDr. Miroslav Souček, CSc.
Published in: Vnitř Lék 2006; 52(6): 632-639
Category: Review

Overview

During recent two decades the progress in the understanding of the pathogenesis of the autoimmune diseases have led to new treatment targets, whose achievement claims new therapeutic advancings. Biological drugs complete or replace conventional immunosuppressive therapies in the treatment of autoimmune diseases. In the treatment of rheumatic diseases are currently used TNF α inhibitors and blockade of the IL-1, in phase of clinical trials or actual registration are agents blocking IL-6, the antibodies against B cell and inhibition of activation of T-cells by costimulating blockade with CTLA4Ig. In the Czech Republic are for treating of rheumatic diseases approved TNF blocking drugs. Treatment with this drugs is centred in biological therapy centres and patients are enroled into Registry of patients treated with anti TNF α drugs (ATTRA), which enable long-term observation of efficacy and toxicity.

Key Words:
rheumatic diseases - TNF α - TNF blocking agents - biological treatment

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