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Is the left ventricle enddiastolic pressure pathological in the older population?


Authors: M. Vytiska 1;  P. Kala 1;  M. Peciar 2;  O. Boček 1;  P. Jeřábek 1;  P. Neugebauer 1;  M. Poloczek 1;  J. Pařenica 1;  J. Špinar 1
Authors‘ workplace: Interní kardiologická klinika Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Jindřich Špinar, CSc., FESC 1;  Stredná zdravotnícka škola, Trenčín, Slovenská republika 2
Published in: Vnitř Lék 2006; 52(1): 40-43
Category: Original Contributions

Overview

Introduction:
The percentage of older population has significantly increased in the recent decades. Morphologic and functional changes of the cardiovascular system go together with ageing. The aim of the study should show the correlation between the age and left ventricular enddiastolic pressure (LVDEP) value.

Methods:
106 patients of the age from 23 to79 years without an organic heart disease and the history of hypertension underwent elective coronary angiography including left ventricle angiography between 1999 and 2002. LVEDP was obtained as an average value from 8 consecutive beats without extrasystoles. According to the relation between increased relative frequency of LVEDP and age patients were divided into two groups: 50 years and older (80 patients) and younger than 50 years (26 patients).

Results:
An average LVEDP value in older population versus younger population was 12.1 ± 5.0 mm Hg vs 8.9 ± 3.4 mm Hg, p < 0.05. Increased LVEDP in yonger population was found in only 11.5 % vs 46.2 % in older group, p < 0.01 and the LVEDP was age dependent, p < 0.05.

Conclusions:
In compliance with about mentioned results we suppose that the age is a factor with impact to LVEDP value. LVEDP values > 12 mm Hg in older population may not be pathological and probably are due to the left ventricle diastolic dysfunction in consequence with ageing.

Key words:
left ventricle enddiastolic pressure (LVDEP) - age


Sources

1. Flegl JL. Alteration in cardiovascular structure and function with advancing age. Am J Cardiol 1986; 12: 33C-44C.

2. Cohen-Solal A, Caveziel B, Laperche T et al. Effect of aging on left ventricular-arterial coupling in man: assesment by means of arterial effective and left ventricular elastances. J Hum Hypertens 1996; 10: 111-116.

3. Burns TR, Klima M, Teasdale TA et al. Morphometry of the aging heart. Mod Patol 1990; 3: 336-342.

4. Davies CH, Ferrara N, Harding SE. Beta-adrenoresceptor function changes with age of subject in myocytes from non-failing human ventricle. Cardiovasc Res 1996; 31: 152-156.

5. Arrighi JA, Dilsizian V, Perrone-Filardi P et al. Improvement of age related impairement in left ventricular diastolic filling with verapamil in the normal human heart. Circulation 1995; 15: 1275-1276.

6. Downes TR, Nomeir AM, Smith KM et al. Mechanism of altered pattern of left ventricular filling with aging in subjects without cardiac disease. Am J Cardiol 1989; 1: 523-527.

7. Meluzín J. Hodnocení diastolické funkce levé komory. Úloha echokardiografie. Cor Vasa 2002; 6: Supplementum.

8. Paleček T, Linhart A, Aschermann M et al. Jednorozměrné barevné mapování transmitrálního průtoku (color M-mode): užitečná metoda pro hodnocení diastolické funkce levé komory. Cor Vasa 2002; 4: Supplementum.

9. Little WC, Downes TR. Clinical evaluation of left ventricular diastolic performance. Prog Cardiovasc Dis 1990; 32: 273-290.

10. Braunwald E et al. Heart disease. 5th ed. Philadelphia: WB Saunders 1997.

11. Michael R, Zile, MD, Dirk L et al. New Concepts in Diastolic Dysfunction and Diastolic Heart Failure: Part II Causal Mechanisms and Treatment. Circulation 2002; 3: 26.

12. Grossmann W. Defining Diastolic Dysfunction. Circulation, 2000; 101: 2020-2021.

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Diabetology Endocrinology Internal medicine

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Internal Medicine

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