Regulation of bone cell metabolism at the cellular and molecular level

Czech version

Authors: V. Palička; P. Živný
Authors‘ workplace: Přednosta: Prof. MUDr. Vladimír Palička, CSc. ; Osteocentrum, Ústav klinické biochemie a diagnostiky Lékařské fakulty a Fakultní nemocnice, Hradec Králové
Published in: Prakt. Lék. 2007; 87(10): 612-615
Category: Various Specialization

Overview

Recent advances in our understanding of the molecular biological processes inside bone tissue and its cells (osteoblasts and osteoclasts) have enabled us to better understand the signalling pathways. Current osteology focuses on the possibilities of influencing stem cells and shifting the balance from adipocytes to osteoblasts. Intercellular signalling, mainly the interaction between osteoblasts and osteoclasts via the RANKL/RANK/OPG system has already led to a direct pharmacological outcome and the development of a new group of drugs.

Key words:
osteology, osteoporosis, stem cells, signal transduction, Wnt signalisation, osteoprotegerin.