Activated Factor VII as the Perioperative Guarrancy of Splenectomy forSevere Form of Corticoresistant ITP

Czech version

Authors: I. Hadačová ¹; J. Hoch ²
Authors‘ workplace: Hematologické oddělení FN Motol, Praha, přednostka prim. MUDr. I. Hochová 2Chirurgická klinika 2. LF UK a FN Motol, Praha, přednosta doc. MUDr. J. Hoch, CSc. ¹
Published in: Prakt. Lék. 2003; (12): 695-696
Category:

Overview

The main treatment of idiopathic thrombocytopenic purpura (ITP) in adults is based onlong-term application of corticosteroids. The different treatment modalities including surgerymay appear necessary in patients with corticoresistant ITP.Demonstrating the case of a 36 year-old man suffering from corticoresistant ITP and severethrombocytopenia the authors discuss contemporary treatment possibilities and call attentionto the preparation for splenectomy by means of activated factor VII.They used NovoSeven (NovoNordisk) after the preparation by concentrated thrombocytes had failed. Splenectomy wentproblem free, the patient healted primarily and the amounts of thrombocytes became stabilised.

Key words:
idiopathic thrombocytopenic purpura (ITP) - corticoresistency - splenectomythrombocytopenia - activated factor VII - Novoseven.

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