Effects of caffeine on cerebral blood flow

Czech version

Authors: Z. Kalita ¹; M. Souček ²; M. Sachová ³
Authors‘ workplace: Neurochirurgická klinika 1. LF UK, Praha
Published in: Prakt. Lék. 2003; (11): 335-337
Category:

Overview

Caffeine, the most widely used central nervous system stimulant, is ingested in coffee, tea, chocolate orsome non-alcoholic drinks. The aim of this study was to investigate the effect of caffeine intake oncerebral blood flow (CBF) using transcranial Doppler ultrasonography. Twenty adult volunteers hadtheir heart rate, blood pressure,end-tidalCO2,and cerebral blood flow velocities in both middle cerebralarteries measured before and 30 minutes after caffeine intake (300 mg). CBF decreased by 19.3 % frombaseline. Cerebral blood flow corrected to et-CO2 = 40mmHg decreased 10 to 19.3 %. Caffeine is a potentcerebral vasoconstrictor due to its antagonism at adenosine receptors.

Key words:
caffeine, transcranial Doppler ultrasonography, cerebral blood flow, adenosine

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Article was published in

General Practitioner

2003 Issue 11