Laboratory monitoring of the treatment with direct oral anticoagulants
Authors:
Lucia Stančiaková 1; Rid Škorňová 1; Jela Ivanková 1; Miroslava Dobrotová 1; Ivana Plameňová 1; Pavol Hollý 1; Tomáš Bolek 2; Matej Samoš 2; Peter Kubisz 1; Ján Staško 1
Authors‘ workplace:
Národné centrum hemostázy a trombózy, Klinika hematológie a transfuziológie JLF UK a UNM, Martin
1; I. interná klinika JLF UK a UNM, Martin
2
Published in:
Forum Diab 2022; 11(2): 102-107
Category:
Overview
Direct oral anticoagulants (DOACs) are currently one of the alternatives of anticoagulant treatment that does not require routine laboratory monitoring, is relatively safe, effective and thanks to the dosage scheme also convenient for the patient. However, there are some clinical situations, in which the laboratory control of their effectiveness is inevitable (e.g. in patients with renal or liver dysfunction, in the case of the suspicion of non-compliance of the patient or his overdose). In the article, we describe mechanism of action of DOACs, their pharmacological properties and related detection of their influence on hemostasis. This information is enriched by the part about clinical aspects of the use of DOACs including life-threatening states and possibilities of the reversal of these agents.
Keywords:
effectiveness – laboratory monitoring – direct oral anticoagulants
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Labels
Diabetology Endocrinology Internal medicineArticle was published in
Forum Diabetologicum
2022 Issue 2
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