The form matters – the benefits of metformin with sustained release

Czech version

Authors: Dana Prídavková; Udovít Šutarík; Marián Mokáň
Authors‘ workplace: I. Interná klinika JLF UK a UN Martin
Published in: Forum Diab 2020; 9(3): 177-183
Category: Review Article

Overview

The oral route of administration is the most natural of all treatments. Sustained and controlled drug delivery allows a constant concentration in the circulation, while delayed release prolongs the duration of action without exposing the metabolism to a shock dose that may be associated with side effects. There are several drug modalities, of which the matrix form of the drug provides better patient compliance than immediate release (IR) drugs, eliminates repeated administration and minimizes fluctuations in levels. The use of a hydrophobic carrier in conjunction with a hydrophilic polymer generally effectively controls the initial rapid release of highly water-soluble drugs, including metformin hydrochloride. Metformin (MET) as the first-line antihyperglycemic drug in patients with type 2 diabetes mellitus (DM2T) is used by about 120 million individuals worldwide [1]. Its biological effect depends on several variables such as form, dose size, solubility, etc. Extended release (XR) MET formulas reduce side effects, improve patient compliance, and ultimately lead to better glycemic outcomes.

Keywords:

diabetes mellitus type 2 – metformin hydrochloride – prolonged release

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