Recent studies and analyses of the results of empagliflozin treatment

Czech version

Authors: Emil Martinka
Authors‘ workplace: Národný endokrinologický a diabetologický ústav, n. o., Ľubochňa
Published in: Forum Diab 2020; 9(3): 198-202
Category:

Overview

5 years after the RCT of the EMPA-REG OUTCOME study, Empagliflozin has established itself not only as an effective and safe drug that lowers glycemia independent of insulin secretion and insulin sensitivity of tissues in all patients with type 2 diabetes mellitus, but also as the strongly recommended choice in patients with cardiovascular (CVD) and/or renal disease, and the preferred treatment in patients at high risk of heart disease, with the aim of reducing heart failure, hospitalization for heart failure (hHF), as well as the onset of and progression of the existing chronic kidney disease (CKD). The RWE (real world evidence) study EMPRISE has confirmed the CV benefit of the reduction of mortality and hospitalization for HF, and also in routine clinical practice. Subsequent sub-analyses of the EMPA-REG OUTCOME study, which were recently presented at the major ADA and EASD world congresses, also pointed to other favorable medical as well as economic parameters. These findings further substantiate and support the importance of iSGLT-2 treatment and its preference in therapeutic approaches.

Keywords:

empagliflozin – EMPA-REG OUTCOME – EMPRISE

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