Mucinózny adenokarcinóm (neintestinálneho typu) vzniknutý v zrelom cystickom teratóme vaječníka - kazuistika
Authors:
Karol Kajo 1; Ladislav Masák 2; Dagmar Sorkovská 3; Miroslava Vallová 1; Michal Kajo 1; Katarína Macháleková 1; Lýdia Heľpianská 4
Authors‘ workplace:
Department of Pathology, St. Elisabeth Cancer Institute, Bratislava, Slovakia
1; Department of Gynaecological Oncology, St. Elisabeth Cancer Institute, Bratislava, Slovakia
2; Department of Clinical Oncology, St. Elisabeth Cancer Institute, Bratislava, Slovakia
3; 1st Department of Oncology, St. Elisabeth Cancer Institute, Bratislava, Slovakia
4
Published in:
Čes.-slov. Patol., 49, 2013, No. 4, p. 141-145
Category:
Original Article
Overview
Malígna somatická transformácia v zrelom cystickom teratóme je zriedkavý fenomén, pri ktorom vzniká zhubný nádor z diferencovaných tkanivových štruktúr niektorého zo zárodočných listov.
Autori prezentujú prípad 38 - ročnej ženy so zrelým cystickým teratómom oboch vaječníkov a mucinóznym adenokarcinómom vzniknutým z endodermálnej zárodočnej línie v pravom ováriu, ktorý imunohistochemicky vykazoval charakteristiky non-intestinálnej diferenciácie. V čase diagnostiky nádor metastázoval do panvových a retroperitoneálnych lymfatických uzlín.
Pacientka bola liečená troma líniami chemoterapie a po 15 mesiacoch od stanovenia diagnózy zomrela za príznakov progresie vo forme masívnej nádorovej propagácie do retroperitoneálnych, mediastinálnych a krčných lymfatických uzlín, infiltrácie retroperitonea a duodena a peritoneálneho rozsevu.
Malígna somatická transformácia v zrelom cystickom teratóme je spojená so zlou prognózou. Najdôležitejším prognostickým faktorom je štádium v čase stanovenia diagnózy.
Kľúčové slová:
ovárium – zrelý cystický teratóm – malígna transformácia – adenokarcinóm – nádorový marker
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Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
2013 Issue 4
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