Fibroblasts – Known or Unknown Cells

Czech version

Authors: S. Brychtová ¹; M. Bezděková ¹; T. Brychta ²
Authors‘ workplace: Laboratoř molekulární patologie a Ústav patologie LF UP, Olomouc ¹; Centrum klinických studií. Agentura Science Pro, spol. s r. o., Nestátní zdravotnické zařízení, Olomouc ²
Published in: Čes.-slov. Patol., 46, 2010, No. 2, p. 29-32
Category: Reviews Article

Overview

Fibroblasts form the main component of the cell tissue microenvironment, and their basic function is to maintain cell integrity and tissue homeostasis. Fibroblasts essentially participate in wound repair. Recently, increased interest has been focused on the role of fibroblasts in cancers, where they are involved in the ransformation of a tumour stroma, and via production of numbers of cytokines and growth factors participate in tumour progression. With regard to their impact in cancerogenesis, fibroblasts become a new target of cancer therapy.

Key words:
fibroblasts – stromal microenvironment – tumor progression

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Article was published in

Czecho-Slovak Pathology

2010 Issue 2