Lymphoma of the Small Intestine
Authors:
J. Mačák; I. Falková; J. Šmardová; L. Křen
Authors‘ workplace:
Ústav patologie Lékařské fakulty Masarykovy univerzity a Fakultní nemocnice, Brno
Published in:
Čes.-slov. Patol., 46, 2010, No. 1, p. 20-24
Category:
Original Article
Overview
A series of eight small intestine lymphomas comprised two cases of follicular lymphoma (FL), one anaplastic large cell lymphoma (ALCL) ALK negative, and five cases of diffuse large B-cell lymphoma. The lymphomas were diagnosed by routine hematoxylin-eosin staining, immunohistochemistry and the FISH method for translocation t(14;18). Immunohistochemistry revealed that the diffuse large B-cell lymphomas were of the non-germinal center type (non GC-DLBCL). In most cases, the tumors formed solid well-circumscribed nodules or resulted in diffuse infiltration of the intestinal wall. In one case of follicular lymphoma, microscopic foci of tumor were found in the intestinal mucosa which spread far from the primary nodule and probably beyond the resection border. It is difficult to ascertain whether this phenomenon represents colonization of pre-existing non-neoplastic follicles by lymphoma or spreading of the tumor within the same tissue. In this case, surgical removal of the lymphoma is problematic.
Key words:
lymphomas – small intestine – immunohistochemistry – FISH
Sources
1. Al-Bahrani, Z.R., Al-Mondhiry, H., Bakir, F. et al.: Clinical and pathological subtypes of primary intestinal lymphoma. Experience with 132 patients over a 14-years period. Cancer 52, 1983, s. 1666–1672.
2. Al-Mondhiry, H.: Primary lymphomas of the small intestine: East-West contrast. Am. J. Hematol. 22, 1986, s. 89–105.
3. Auger, M.J., Allan, N.C.: Primary ileocaecal lymphoma. A study of 22 patients. Cancer 65, 1990, s. 358–361.
4. Bende, R.J., Smit, L.A., Bossenbroek, J.G.: Primary follicular lymphoma of the small intestine. α4ß7 expression and immunoglobulin configuration suggest an origin from local antigen-experienced B cell. Am. J. Pathol. 162, 2003, s. 105–113.
5. Carey, M.J., Medeiros, L.J., Roepke, J.E. et al.: Primary anaplastic large cell lymphoma of the small intestine. Am. J. Clin.Pathol. 112, 1999, s. 696–671.
6. Cooper, B.T., Read, A.E.: Small intestine lymphoma. World J.Surg. 9, 1985, s. 930–937.
7. Domizio, P., Owen, R.A., Shepard, N.A. et al.: Primary lymphoma of the small intestine. Am. J. Surg. Pathol. 17, 1993, s. 429–442.
8. Dragosics, B., Bauer, P., Radaszkiewicz, T.: Primary gastrointestinal non-Hodgkin’s lymphomas: a retrospective clinco-pathological study of 150 cases. Cancer 55, 1985, s. 1060–1073.
9. Griesser, H., Henry, M., Boie, C. et al.: Large-cell anaplastic lymphoma of the gastrointestinal tract: an immuno- and genotypic study on archival material. Hematol. Pathol. 8, 1994, s. 121–134.
10. Hamilton, S.R., Aaltonen, L.A.: Tumours of the digestive system. Pathology & Genetics, WHO classification, IARC Press, Lyon 2000, s. 84–85.
11. Held, G., Pfreundschuh, M.: Hematology: Germinal center or nongerminal center DLBCL? Nat. Rev. Clin. Oncol. 6, 2009, s. 188–190.
12. Kwon, M.S., Go, J.H., Choi, J.S. et al.: Critical evaluation of Bcl-6 protein expression in diffuse large B-cell lymphoma of the stomach and small intestine. Am. J. Surg. Pathol. 27, 2003, s. 790–798.
13. LeBrun, D.P., Kamel, O.W., Cleary, M.L. et al.: Follicular lymphomas of the gastrointestinal tract. Am. J. Pathol. 140, 1992, s. 1327–1335.
14. Levison, D.A., Hall, P.A., Blackshaw, A.J.: The gut-associated lymphoid tissue and its tumors. In: Williams, G.Z.: Current Topics in Gastrointestinal Pathology, Berlin, Springer Verlag, 1989, s. 134–175.
15. O’Rourke, M.G.E., Lancashire, R.P., Vattoune, J.R.: Lymphomas of the small intestine. Aus.N.Z.J.Surg. 56, 1986, s. 351–355.
16. Pals, S.T., de Gorter, D.J.J., Spaargaren, M.: Lymphoma dissemination: the other face of lymphocyte homing. Blood 110, 2007, s. 3102–3111.
17. Pearson, J.M., Borg-Grech, A.: Primary Ki-1 (CD30)- positive, large cell, anaplastic lymphoma of the esophagus. Cancer 68, 1991, s. 418–421.
18. Swerdlow, S.H., Campo, E., Harris, N.L.: WHO Classification of Tumours of Haematopoietic and Lymphoid tissue. WHO Press, Lyon, 2008, s. 439.
Labels
Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
2010 Issue 1
Most read in this issue
- Histopathological Classification of Idiopathic Interstitial Pneumonias
- Lymphoma of the Small Intestine
- Caspase 1, Superoxiddismutase (D-mutase) and Calretinin Expression in the Placenta and in the Basal Decidua in Preeclampsia
- Analysis of Bone Marrow Angiogenesis in Multiple Myeloma