Giant Cell Fibroblastoma in a 62-Year-Old Patient. A Case Report
Authors:
M. Zámečník 1; A. Chlumská 1,2
Authors‘ workplace:
Bioptická laboratoř s. r. o., Plzeň, Czech Republic
1; Šikl’s Department of Pathology, Faculty Hospital, Charles University, Plzeň, Czech Republic
2
Published in:
Čes.-slov. Patol., 44, 2008, No. 3, p. 75-78
Category:
Original Article
Overview
A case of giant cell fibroblastoma in a 62-year-old male is described. The 2x1.5x1.5 cm tumor was excised from the right supraclavicular area. Histologically, it was typical with exceptions that the typical pseudovascular spaces were seen only focally and the neoplastic cells were closely spatially associated with lymphocytes and plasmocytes. This association was suggestive of emperipolesis. The unusual clinicopathologic features caused some diagnostic difficulty.
Key words:
dermatofibrosarcoma protuberans - emperipolesis - giant cell fibroblastoma - myxoinflammatory fibroblastic sarcoma - Rosai-Dorfman disease
Sources
1. Chu P., LeBoit P.E.: Histologic features of cutaneous histiocytosis (Rosai-Dorfman disease): study of cases both with and without systemic involvement. J. Cutan. Pathol. 1992, 19, p. 201-206.
2. Cin P.D., Sciot R., de Wever L., et al.: Cytogenetic and immunohistochemical evidence that giant cell fibroblastoma is related to dermatofibrosarcoma protuberans. Genes Chromosomes Cancer 1996, 15, p. 73-75.
3. Derier J., Ferrand M.: Dermatofibrosarcomes progressifs et recidivans ou fibrosarcomes de la peau. Ann. Dermatol. Syphiligr. 1924, 5, p. 545-562.
4. Frierson H.F., Cooper P.H.: Myxoid variant of dermatofibrosarcoma protuberans. Am. J. Surg. Pathol. 1983, 7, p. 445-450.
5. Goldblum J.R.: Giant cell fibroblastoma: a report of three cases with histologic and immunohistochemical evidence of a relationship to dermatofibrosarcoma protuberans. Arch. Pathol. Lab. Med. 1996, 120, p. 1052-1055.
6. Jha P., Moosavi C., Fanburg-Smith J.C.: Giant cell fibroblastoma: an update and addition of 86 new cases from Armed Forces Institute of Pathology, in honor of Dr. Franz M. Enzinger. Ann. Diagn. Pathol. 2007, 11, p. 81-88.
7. Kinkor Z., Mukensnabl P., Michal M.: Inflammatory myxohyaline tumor with massive emperipolesis. Pathol. Res. Pract. 2002, 198, p. 639-642.
8. Kong Y., Kong J., Shi D., et al.: Cutaneous Rosai-Dorfman disease. A clinical and histopathologic study of 25 cases in China. Am. J. Surg. Pathol. 2007, 31, p. 341-350.
9. Lopes L.F., Bacchi M.M., Coelho K.I., et al.: Emperipolesis in a case of B-cell lymphoma: a rare phenomenon outside of Rosai-Dorfman disease. Ann. Diagn. Pathol. 2003, 7, p. 310-313.
10. Meis-Kindblom J.M., Kindblom L.G.: Acral myxoinflammatory fibroblastic sarcoma: a low-grade tumor of the hands and feet. Am. J. Surg. Pathol. 1998, 22, p. 911-924.
11. Michal M.: Inflammatory myxoid tumor of the soft parts with bizarre giant cells. Pathol. Res. Pract. 1998, 194, p. 529-533.
12. Michal M., Zamecnik M.: Giant cell fibroblastoma with a dermatofibrosarcoma protuberans component. Am. J. Dermatopathol. 1992, 14, p. 549-552.
13. Mongomery E.A., Devaney K.O., Giordano T.J., et al.: Inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg-like cells: a distinctive lesion with features simulating inflammatory conditions, Hodgkin’s disease, and various sarcomas. Mod. Pathol. 1998, 11, p. 384-391.
14. Mongomery E.A., Meis J.M., Frizzera G.: Rosai-Dorfman disease of soft tissue. Am. J. Surg. Pathol. 1992, 16, p. 122-129.
15. Motta L., McMenamin M.E., Thomas M.A., et al.: Crystal deposition in a case of cutaneous Rosai-Dorfman disease. Am. J. Dermatopathol. 2005, 27, p. 339-342.
16. O’Brien K.P., Seroussi E., Dal Cin P., et al.: Various regions with the alpha-helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastomas. Genes Chromosomes Cancer 1998, 23, p. 187-193.
17. Padilla-Rodriguez A.L., Bembassat M., Lazaro M., et al.: Intraabdominal follicular dendritic cell sarcoma with pleomorphic features and aberrant expression of neuroendocrine markers: report of case with immunohistochemical analysis. Appl. Imunohistochem. Mol. Morphol. 2007, 15, p. 346-352.
18. Paulli M., Rosso R., Kindl S., et al.: Immunophenotypic characterization of the cell infiltrate in five cases of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Hum. Pathol. 1992, 23, p. 647-654.
19. Quaglino P., Tomasini C., Novelli M., et al.: Immunohistologic findings and adhesion molecule pattern in primary pure cutaneous Rosai-Dorfman disease with xanthomatous features. Am. J. Dermatopathol. 1998, 20, p. 393-398.
20. Rosai J., Dorfman R.F.: Sinus histiocytosis with massive lymphadenopathy: a newly recognized benign clinicopathologic entity. Arch. Pathol. Lab. Med. 1969, 87, p. 63-70.
21. Shen R., Wen P.: Clear cell renal cell carcinoma with syncytial giant cells: a case report and review of the literature. Arch. Pathol. Lab. Med., 2004, 128, p. 1435–1438.
22. Saxena S., Beena K.R., Bansal A., et al.: Emperipolesis in a common breast malignancy. Acta Cytol. 2002, 46, p. 883-886.
23. Shmookler B.M., Enzinger F.M.: Giant cell fibroblastoma: a. peculiar childhood tumor. Lab. Invest. 1982, 46, p. 76(A).
24. Shmookler B.M., Enzinger F.M., Weiss S.W.: Giant cell fibroblastoma. A juvenile form of dermatofibrosarcoma protuberans. Cancer 1989, 64, p. 2154-2161.
25. Taylor R.W.: Sarcomatous tumors resembling in some respects keloid. Arch. Dermatol. 1890, 8, p. 384-387.
26. Terrier-Lacombe M.J., Guillou L., Maire G., et al.: Dermatofibrosarcoma protuberans, giant cell fibroblastoma, and hybrid lesions in children: clinicopathologic comparative analysis of 28 cases with molecular data. A study from the French Federation of Cancer Centers Sarcoma Group. Am. J. Surg. Pathol. 2003, 27, p. 27-39.
27. Wu M., Burstein D.E.: Emperipolesis in pleural mesothelial cells in a patient with chronic lymphocytic leukemia. Acta Cytol. 2005, 49, p. 692-694.
28. Yokoo H., Isoda K., Nakazato Y.: Retroperitoneal epithelioid angiomyolipoma leading to fatal outcome. Pathol. Int. 2000, 50, p. 649-654.
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Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
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