Syndecan-1 (CD138): anImmunohistochemical Marker of Plasma CellNeoplasms

Czech version

Authors: F. Fakan; L. Boudová; C. Hejda
Published in: Čes.-slov. Patol., , 2002, No. 1, p. 33-36
Category:

Overview

The immunohistochemical detection of syndecan-1 (belonging to the cluster CD138) is a sensitiveand reliable method for identifying normal and neoplastic plasma cells. It may be used in para-ffinmbedded bone marrow specimens, as well as in extramedullary tumours of unknown origin.The three anaplastic tumours reported by us in the lymph node, the gingiva, and pleura werenegative for other markers, but the syndecan-1 positivity elucidated their plasmocytic histogenesis.

Key words:
plasma cells - anaplastic myeloma - syndecan-1 (CD138) - immunohistochemistry

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Article was published in

Czecho-Slovak Pathology

2002 Issue 1