DipeptidylAminopeptidase IV in Differential Diagnosis of ThyroidTumors: Description of Method and Results of PilotStudy of 200 Cases

Overview

The use of dipeptidyl aminopeptidase IV (DPP IV) staining by azo-coupling in preoperative andintraoperative diagnostics of thyroid lesions is presented. In a series of 200 histologically confir-med cases examined, the sensitivity and the specificity were 71 % and 99 %, respectively in 124smears, and 70 % and 94 %, respectively in 189 frozen sections. DPP IV expression showed highnegative predictive value as well.DPP IV is suggested as an additional tool in the preoperative and intraoperative diagnostics ofthyroid lesions.

Key words:
dipeptidyl aminopeptidase IV - thyroid tumors - differential diagnosis - aspirationcytology