Has prenatal ultrasound diagnosis of congenital kidney anomalies improved?
Authors:
Flögelová Hana 1,2; Šuláková Soňa 3; Šarapatka Jan 4; Čivrný Jakub 5; Laubová Jana 6
Authors‘ workplace:
Lékařská fakulta, Univerzita Palackého v Olomouci
1; Dětská klinika, Fakultní nemocnice Olomouc
2; Novorozenecké oddělení, Fakultní nemocnice Olomouc
3; Urologická klinika, Fakultní nemocnice Olomouc
4; Radiologická klinika, Fakultní nemocnice Olomouc
5; Nefrologická ambulance, Dětská klinika, Masarykova nemocnice, Ústí nad Labem
6
Published in:
Čes-slov Pediat 2023; 78 (6): 303-307.
Category:
Original Papers
doi:
https://doi.org/10.55095/CSPediatrie2023/033
Overview
Objective: To assess advances in detecting severe kidney anomalies by prenatal ultrasound (US) screening over the last 13 years.
Methods: The study compared two groups of children born in the University Hospital Olomouc in 2005-2008 (Group A) and in 2018-2020 (Group B) who had severe congenital anomalies of the kidney and urinary tract (CAKUT) requiring surgery by two years of age. Statistical analysis was performed using Fisher’s exact test.
Results: Both groups showed a similar range of severe CAKUT requiring surgery: ureteropelvic junction obstruction, obstructed or refluxing megaureter, posterior urethral valves, and duplicated collecting system associated with reflux or obstruction. Group A comprised 16 surgically treated children, of whom seven (44%) had negative prenatal US findings. Group B consisted of 15 surgically treated children, with only one (7%) having a negative prenatal US scan. The difference was statistically significant (p=0.037).
Conclusion: Results from the Olomouc region suggest that the detection of most severe CAKUT by prenatal US has considerably improved over the last 13 years.
Sources
1. Seikaly MG, Ho PL, Emmett L, et al. Chronic renal insufficiency in children: the 2001 Annual Report of the NAPRTCS. Pediatr Nephrol 2003; 18: 796–804.
2. ESPN/ERA-EDTA Registry. An update on the Registry February 2022. PRD distribution at start of KRT in 2019 [online]. [cit. 9-3-2023]. Dostupné na: https://espn-reg.org/files/AR2019.pdf
3. Rees L, Bockenhauer D, Webb NJA, Punaro MG. Paediatric Nephrology. 3rd ed. New York, USA: Oxford University Press 2019: 58.
4. Gregor V, Šípek A, Calda P, et al. Prenatální diagnostika vrozených vad diagnostikovaných ultrazvukem, Česká republika 1994-2007. Čes Gynek 2008; 73(6): 340–350.
5. Výbor ČGPS ČLS JEP. Zásady dispenzární péče v těhotenství. Sbírka doporučených postupů č. 1/2021: 1–3.
6. Výbor ČGPS ČLS JEP. Pravidelná ultrazvuková vyšetření v průběhu prenatální péče. Sbírka doporučených postupů č. 1/2022: 1–3.
7. Nguyen HT, Benson CB, Bromley B, et al. Multidisciplinary consensus of the classification of the prenatal and postnatal urinary tract dilation (UTD classification system). J Pediatr Urol 2014; 10: 982–999.
8. Hálek J, Flögelová H, Michálková K, et al. Diagnostic accuracy of postnatal ultrasound screening for urinary tract abnormalities. Pediatr Nephrol 2010; 25 (2): 281–287.
9. Dugoff L. Ultrasound diagnosis of structural abnormalities in the first trimester. Prenat Diagn 2002; 22: 316–320.
10. Queisser-Luft A, Stolz G, Wiesel A, et al. Malformations in newborn: results based on 30,940 infants and fetuses from the Mainz congenital birth defect monitoring system (1990-1998). Arch Gynecol Obstet 2002; 266: 163–167.
11. Madarikan BA, Hayward C, Roberts GM, Lari J. Clinical outcome of fetal uropathy. Arch Dis Child 1988; 63: 961–963.
12. Livera LN, Brookfield DS, Egginton JA, Hawnaur JM. Antenatal ultrasonography to detect fetal renal abnormalities: a prospective screening programme. BMJ 1989; 298: 1421–1423.
13. Sanghvi KP, Merchant RH, Gondhalekar A, et al. Antenatal diagnosis of congenital renal malformations using ultrasound. J Trop Pediatr 1998; 44: 235–239.
14. Dobrovanov OY. Efficacy and sensitivity of prenatal and postnatal ultrasound screening of congenital developmental anomalies of kidneys in Slovakia. Wiad Lek 2021; 74(3 p.I): 450–454.
Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
![Issue 6](https://www.prolekare.cz/media/cache/resolve/journal_issue/media/image_pdf/e62a2a20820bd0ba3a7137a6eb332303.jpg)
2023 Issue 6
Most read in this issue
- Brief resolved unexplained event (BRUE)
- Emotionally unstable adolescents – a current challenge of child psychiatry and pediatrics
- The current state of fetal imaging by magnetic resonance imaging
- Hypophosphatasia: A rare disease with an easy diagnosis and available therapy