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Severe autoimmune encephalitis in a seventeen-year-old boy – case report


Authors: A. Liptáková 1;  J. David 1;  J. Jonáš 2;  N. Šimánková 1;  V. Koukolská 3;  R. Valkovičová 4
Authors‘ workplace: Pediatrická klinika 2. LF UK a FN Motol, Praha 1;  Klinika anesteziologie, resuscitace a intenzivní medicíny 2. LF UK a FN Motol, Praha 2;  Klinika zobrazovacích metod 2. LF UK a FN Motol, Praha 3;  Klinika dětské neurologie 2. LF UK a FN Motol, Praha 4
Published in: Čes-slov Pediat 2020; 75 (8): 474-478.
Category: Case Report

Overview

Autoimmune encephalitis represent a heterogenous group of diseases which is based on an immune response against neuronal autoantigens with production of antibodies. Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is characterised by diffused involvement of cortical and subcorticale structures and represents the most frequent type of autoimmune encephalitis in adults which can manifest also in children and adolescents.

We present a case report of a seventeen-year-old boy with severe anti-NMDAR encephalitis and typical initial psychiatric symptomatology.

Keywords:

autoimmune encephalitis – anti-NMDAR encephalitis – children – Pediatrics


Sources

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3. Dalmau J, Gleichman AJ, Hughes EG, et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 2008; 7: 1091–1098.

4. Kučerová J, Vališ M, Masopust J. Encefalitida s protilátkami proti NMDA receptorům. Cesk Slov Psychiatr 2014; 110 (5): 272–277.

5. Dalmau J, Rodenfeld M. Paraneoplastic and autoimmune encefalitis. Up to date 2020. http://www.uptodate.com.

6. Mikolášek P, Aulická Š, Homola L, et al. Anti-NMDAR encefalitida v dětském věku – kazuistika. Cesk Slov Neurol N 2017; 113 (2): 224–227.

7. Jakubčiaková V, Slonková J. Autoimunitní encefalitidy – kazuistiky. Cesk Slov Neurol N 2016; 79/112 (6): 707–714.

8. Češková E, Ustohal L. Neuroleptický maligní syndrom, přehledový článek a kazuistiky. Cesk Slov Psychiat 2019; 115 (1): 27–31.

Labels
Neonatology Paediatrics General practitioner for children and adolescents
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