Incidence of idiopathic enteric inflammations in children and adolescents in the Plzeň (Pilsen) Region in 2001–2011.
A Prospective study
Authors:
J. Schwarz; J. Sýkora
Authors‘ workplace:
Dětská klinika FN a LF UK, Plzeň
přednosta prof. MUDr. J. Kobr, Ph. D.
Published in:
Čes-slov Pediat 2013; 68 (3): 149-156.
Category:
Original Papers
Overview
The objective of the work was to verify the incidence of idiopathic bowel disease (IBD) inflammations in the Plzeň Region (PLK) in children up to 19 years old and to determine, whether there are any geographic or demographic differences in their incidence in a precisely defined area of PLK.
Method:
The data of newly diagnosed patients of the Children Clinic, Pilsen Faculty Hospital, fulfilling the IBD diagnostic criteria were collected prospectively. IBD was diagnosed according to recommendations of professional medical societies.
Results:
128 patients were enrolled into the study, 74 of them with the Crohn’s disease and 52 children with ulcerous colitis (UC), and two patients were found to suffer from inflammatory bowel disease unclassified. The age median at the time of diagnosis in the group of up to 19 years of age proved to be 14.1 years (range 1.4–18.3). In the group of patients up to 15 years these data were 11 .7 (1.4–15). Incidence for 100,000 children up to 19 years of age/year in PLK was 9.24 (IBD), 5.14 (CD) and 4.03 (UC), the data for the group up to 15 years being 7.28 (IBD), 4.37 (CD) and 2.91 (UC).
Conclusion:
Information obtained about 128 children and adolescents suffering from BD in PLK in the period of 2001-2011 demonstrated increasing incidence compared with the period of 1900-2001 and a shift in establishment of diagnosis to the younger age group, which corresponds to the worldwide trends. A higher incidence was demonstrated in town with the population of 5 to 10,000 (p<0.01), communities with population up to 5 thousands had lower IDB incidence than the towns (p<0.01). A higher incidence of CD was found in women in the Tachov district (p<0.01), and in men of the Plzeň – North district (p<0.01), where the incidence of UC was higher (p<0.01). The significantly lower incidence of IBD (p<0.01) and UC (p<0.05) occurred in the Klatovy district.
The results made it clear that life environment plays a role in the development of IBD. Specific risk factors of the environment in the development of IBD should be analyzed in the Tachov district and Plzeň – North district prospectively in relation to the development of IBD.
Key words:
Pilsen region, child age, incidence, idiopathic bowel disease inflammation, Crohn’s disease, ulcerous colitis
Sources
1. Benchimol EI, Fortinsky KJ, Gozdyra P, et al. Epidemiology of pediatric inflammatory bowel disease: a systematic review of international trends. Inflamm Bowel Dis 2011; 17: 423–439.
2. Working IBD, Group of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition. Inflammatory bowel disease in children and adolescents: recommendations for diagnosis – the Porto criteria. J Pediatr Gastroenterol Nutr 2005; 41 (1): 1–7.
3. van Assche G, Dignass A, Panes J, et al. The second European evidence-based consensus on the diagnosis and management of Crohn’s disease: definitions and diagnosis. Journal of Crohn’s and Colitis 2010; 4 (1): 7–27.
4. Bronský J, et al. Doporučení Pracovní skupiny dětské gastroenterologie a výživy ČPS pro diagnostiku a léčbu nespecifických střevních zánětů u dětí. Čes-slov Pediat 2012; 67 (Suppl 2).
5. Český statistický úřad. Databáze demografických údajů za obce ČR. http://www.czso.cz/cz/obce_d/index.htm.
6. Český statistický úřad. Statistická ročenka Plzeňského kraje 2011. http://www.czso.cz/csu/2011edicniplan.nsf/krajp/321011-11-xp.
7. Český statistický úřad. http://www.czso.cz/csu/2011edicniplan.nsf/t/60003B195D/$File/32101111ch.pdf.
8. Benchimol EI, Fortinsky KJ, Gozdyra P, et al. Epidemiology of pediatric inflammatory bowel disease: A systematic review of international trends. Inflamm Bowel Dis 2011; 17: 423–439.
9. Pozler O, Malý J, Bónová O, et al. Idiopatické střevní záněty u dětí a dospívajících v ČR v letech 1990–2001. Čes-slov Pediat 2004; 2: 63–69.
10. Molodecky AN, Soon SI, Rabi MD, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology 2012; 142 (1): 46–54.
11. Henderson P, Rogers P, Gillett PM, Wilson DC, British Society of Paediatric Gastroenterology, Hepatology and Nutrition/Neonatal Nutrition Network. The epidemiology and natural history of paediatric inflammatory bowel disease in a UK region: a prospective 14-year study. Arch Dis Child 2012; 97 (Suppl 1): A53–A54.
12. Gearry RB, et al. Population – based cases control study of inflammatory bowel disease risk factors. J Gastroenterol Hepatol 2010; 25 (2): 325–333.
13. Hansen TS, et al. Environmental factors in inflammatory bowel disease: a case control study based on a Danish inception kohort. J Crohns Colitis 2011; 5 (6): 577–584.
14. Lakatos PL. Environmental factors affecting inflammatory bowel disease: have we made progress? Dig Dis 2009; 27: 215–225.
15. Hugot JP, Alberti C, Berrebi D, et al. Crohn’s disease: the cold chain hypothesis. Lancet 2003; 362: 2012–2015.
16. Bernstein CN, Rawsthorne P, Cheang M, et al. A population-based case control study of potential risk factors for IBD. Am J Gastroenterol 2006; 101: 993–1002.
17. Radon K, Windstetter D, Poluda AL, et al. Contact with farm animals in early life and juvenile inflammatory bowel disease: a case control study. Pediatrics 2007; 120: 354–361.
18. Binder V. Genetic epidemiology in inflammatory bowel disease. DigDis 1998; 16: 351–355.
19. Kolek A, Janout V, Tichy M, et al. The incidence of inflammatory bowel disease is increasing among children 15 years old and younger in the Czech Republic. J Pediatr Gastroenterol Nutr 2004; 38: 362–363.
20. Karolewska-Bochenek K, Lazowska-Przeorek I, Albrecht P, et al. Epidemiology of inflammatory bowel disease among children in Poland. Digestion 2009; 79: 121–129.
21. Ahmed M, Davies IH, Hood K, et al. Incidence of paediatric inflammatory bowel disease in South Wales. Arch Dis Child 2006; 91: 344–345.
22. Sawczenko A, Sandhu BK, Logan RFA, et al. Prospective survey of childhood inflammatory bowel disease in the British Isles. Lancet 2001; 357: 1093–1094.
23. Sincic BM, Vucelic B, Persic M, et al. Incidence of inflammatory bowel disease in Primorsko-goranska County, Croatia, 2000–2004: A prospective population-based study. Scand J Gastroenterol 2006; 41: 437–444.
24. Turunen P, Kolho K-L, Auvinen A, et al. Incidence of inflammatory bowel disease in Finnish children, 1987–2003. Inflamm Bowel Dis 2006; 12: 677–683.
25. Ott C, Obermeier F, Thieler S, et al. The incidence of inflammatory bowel disease in a rural region of Southern Germany: a prospective population-based study. Eur J Gastroenterol Hepatol 2008; 20: 917–923.
26. Grieci T, Butter A. The incidence of inflammatory bowel disease in the pediatric population of southwestern Ontario. J Pediatr Surg 2009; 44: 977–980.
27. Perminow G, Brackmann S, Lyckander LG, et al. A characterization in childhood inflammatory bowel disease, a new population-based inception cohort from south-eastern Norway, 2005–07, showing increased incidence in Crohn’s disease. Scand J Gastroenterol 2009; 44: 446–456.
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Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2013 Issue 3
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Incidence of idiopathic enteric inflammations in children and adolescents in the Plzeň (Pilsen) Region in 2001–2011.
A Prospective study