#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Cephalosporins 4th Generation in Management of Febrile Neutropenia in High Risk Children with Cancer. A Prospective Study Department of Pediatric Oncology, Faculty Hospital Motol


Authors: P. Kavan 1;  O. Nyč 2;  E. Drahokoupilová 1;  S. Stejskalová 1
Authors‘ workplace: Klinika dětské onkologie 2. LF UK a NFM, Praha, 1 přednosta prof. MUDr. J. Koutecký, DrSc. Ústav klinické mikrobiologie 2. LF UK a FNM, Praha, 2 přednostka doc. MUDr. A. Součková, CSc.
Published in: Čes-slov Pediat 2001; (2): 100-103.
Category:

Overview

Despite to development and use a new, modern broad-spectrum antibiotic infection remains the most serious complication of intensive anticancer therapy in children. The spectrum of microorganisms in neutropenic cancer patients has changed during the last two decades. In most centers, gram-positive cocci have become the most common isolates. Treatment of these critically ill patients has become the major unsolved problem. We performed a prospective randomized study to determine the efficacy of both cephalosporins 4th generation in combination with glykopeptide in cancer children with febrile neutropenia. There were 19 patients with advanced malignancies in group A and 17 in group B. Both groups were comparable according to age, sex, disease and treatment intensity. More than 60% of patients (68% in group A and 64% in group B) respond well and did not received additional 2nd or 3rd line therapy. Three patients died due to sepsis. There were no cephalosporins related toxicity’s. There was no difference between cefapim and cefpirom effect. In conclusion combination of cephalosporins 4th generation and glykopeptide as an empiric first line choice seems to be very effective promising.

Key words:
febrile neutropenia, children, antibiotics, cephalosporins

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Labels
Neonatology Paediatrics General practitioner for children and adolescents

Article was published in

Czech-Slovak Pediatrics


2001 Issue 2

Most read in this issue
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#