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Up-to-date Situation with Gonorrhoea:
Prague STI Center Results – Antimicrobial Susceptibility Monitoring


Authors: M. Kojanová 1;  I. Kuklová 1;  M. Slováčková 2;  J. Běláček 3;  J. Štork 1
Authors‘ workplace: Dermatovenerologická klinika 1. LF UK a VFN, Praha přednosta prof. MUDr. Jiří Štork, CSc. 1;  Ústav lékařské biochemie a laboratorní diagnostiky 1. LF UK a VFN, Praha přednosta prof. MUDr. Tomáš Zima, DrSc., MBA 2;  Ústav biofyziky a informatiky 1. LF UK přednosta prof. MUDr. RNDr. Jiří Beneš, CSc. 3
Published in: Čes-slov Derm, 89, 2014, No. 5, p. 240-248
Category: Venereology

Overview

The year 2012 in the Czech Republic experienced a dramatic increase in the number of gonorrhoea cases of 67.1% over the prior year.

In recent years we have been witnessing worsening situation due to the decreased effects of antimicrobial medication on Neisseria gonorrhoeae and, at the same time, a growth in the number of new HIV infections.

In the course of our monitoring gonorrhoea patients, the STI Centre of the Dermatovenereology Clinic of the First Faculty of Medicine, Charles University and General Teaching Hospital in Prague has found a greater incidence of resistance to antimicrobial medication. Data from the period 2006 – 2010 and 2012 – 2013, show increased resistance to azithromycin from 3.9% to 22.9 %, respectively. Resistance to cefotaxim increased from 0.6% to 10.0%, and to penicilin from 86.5% to 100.0%; while resistance to ciprofloxacin (from 71.3% to 68.6%) and tetracyklin (from 80.3 % to 71,4 %) did not increase during this period, resistance levels remained exceptionally high. There is a statistical evidence that the nature and application of antibiotic therapy in the Czech Republic have not substantially changed in recent years.

Our article presents an overview of findings regarding HIV and gonorrhoea in the Czech Republic ad demonstrates the correlation of their transmissions, depicts the changes in sensitivity of gonorrhoea to antimicrobial medication, and presents guidelines for treatment.

It is shown that the monitoring of the epidemiological occurrence of gonorrhoea and related effective therapy helps prevent the spread of HIV infections.

Key words:
STI – gonorrhoea – N. gonorrhoeae – MSM – resistance – HIV


Sources

1. ARAL, S. O., FENTON, K. A., HOLMES, K. K. Sexually transmitted diseases in the USA: temporal trends. Sex. Transm. Infect, 2007, 83, p. 257–266.

2. BIGNELL, C. 2009 European (IUSTI/WHO) guideline on the diagnosis and treatment of gonorrhoea in adults. Int. J. STD AIDS, 2009, 20, p. 453–457.

3. BIGNELL, C., FITZGERALD, M. UK national guideline for the management of gonorrhoea in adults, 2011. Int. J. STD AIDS, 2011, 22, p. 541–547.

4. BIGNELL, C., UNEMO, M. 2012 European guideline on the diagnosis and treatment of gonorrhoea in adults. Dostupná na: http://www.iusti.org/regions/europe/pdf/2012/Gonorrhoea_2012.pdf

5. BOLAN, G. A., SPARING, P. F., WASSERHEIT, J. N. The Emerging Threat of Untreatable Gonococcal Infection. N. Engl. J. Med., 2012, 366, p. 485–487.

6. CÁCERES, C. F., KONDA, K., SEGURA, E. R., LYERLA, R. Epidemiology of male same-sex behaviour and associated sexual health indicators in low- and middle-income countries: 2003–2007 estimates. Sex. Transm. Infect., 2008, 84 (Suppl), p. 49–56.

7. CAMPOS-OUTCAL, D. CDC update on gonorrhea: expand treatment to limit resistance. J. Fam. Pract., 2011, 60, p. 736–740.

8. Centers for disease control and prevention (CDC). 2009 Sexually Transmitted Diseases Surveillance. Gonorrhea. Dostupné na: http:// www.cdc.gov/STD/stats09/gonorrhea.htm.

9. Centers for disease control and prevention (CDC). 2010 Sexually Transmitted Diseases Surveillance: Gonorrhea. 10. Centers for disease control and prevention (CDC). Sexually transmitted disease treatment guidelines. 2010, MMWR, 59, p. 1-110.

11. Centers for disease control and prevention (CDC): Update to CDC’s Sexually Transmitted Diseases Treatment Guidelines. 2010 Oral cephalosporins no longer a recommended treatment for gonococcal infections. MMWR, 2012, 61, p. 590–594.

12. COLE, M. J., UNEMO, M., HOFFMANN, S. et al. The European gonococcal antimicrobial surveillance programme. Euro. Surveill., 2009, 16, p. 19995.

13. European centre for (ECDC): Sexually transmitted infections in Europe 1990 disease prevention and control – 2010. ECDC Surveillance report, 2012, p. 1–69.

14. FENTON, K. A., LOWNDES, C. M. Recent trends in the epidemiology of sexually transmitted infections in the European Union. Sex. Transm. Infect., 2004, 80, p. 255–263.

15. FOWLER, T., CALAY, M., JOHAL, R. et al. Previous history gonococcal infection as a risk factor in patients presenting with gonorrhoea. Int. J. STD AIDS, 2010, 21, p. 277–278.

16. FUNG, M., SCOTT, K. C., KENT, C. K. Chlamydial and gonococcal reinfection among men: a systematic review of data to evaluate the need for retesting. Sex. Transm. Infect., 2007, 83, p. 304–309.

17. GONOCOCCAL ISOLATE SURVEILLANCE PROJECT (GISP). Dostupné na: http://www.cdc.gov/std/GISP.

18. CHAN, C. H., McCABE, C. J., FISMAN, D. N. Core groups, antimicrobial resistance and rebound in gonorrhoea in North America. Sex. Transm. Infect., 2012, 88, p. 200–204.

19. JAKOPANEC, I., GRJIBOVSKI, A. M., NILSEN, O. et al. Syphilis epidemiology in Norway, 1992–2008: resurgence among men who have sex with men. BMC Infect. Dis., 2010, 10, p. 1–9.

20. JACOPANEC, I., GRJIBOVSKI, A. M., NILSEN, O. et al. Trends in HIV infection surveillance data among men who have sex with men in Norway, 1995–2011. BMC Public Health, 2013, 13, p. 1–10.

21. JOHNSON, L. F., LEWIST, D. A. The Effect of Genital Tract Infections on HIV-1 Shedding in the Genital Tract: A Systematic Review and Meta-Analysis. Sex. Transm. Dis., 2008, 35, 11, p. 946–959.

22. KUKLOVÁ, I., KOJANOVÁ, M.,VELČEVSKÝ, P. Současný stav problematiky sexuálně přenosných onemocnění. Čes.-slov. derm., 2008, 83, s. 115–121.

23. KUKLOVÁ, I., VELČEVSKÝ, P., KOJANOVÁ, M. et al. Analýza příčin stoupající incidence syfilidy v pražské populaci. Čes.-slov. derm., 2009, 84, s. 350–355.

24. MALÝ, M., NĚMEČEK, V., STAŇKOVÁ, M. et al. Trendy vývoje a výskyt HIV/AIDS v ČR v roce 2012. Tisková zpráva Národní referenční laboratoře pro HIV/AIDS. Zprávy centra epidemiologie a mikrobiologie, SZÚ, 2012, 21, s. 398–399.

25. MALÝ, M., NĚMEČEK, V., ZÁKOUCKÁ, H. et al. Výskyt a šíření HIV/AIDS v ČR v roce 2011. Zprávy centra epidemiologie a mikrobiologie, SZÚ, 2012, 21, s. 388–398.

26. Národní referenční laboratoř pro HIV/AIDS, Tisková zpráva, Trendy vývoje a výskyt HIV/AIDS v ČR v roce 2013. Dostupné na: http://www.szu.cz/uploads/documents/CeM/HIV_AIDS /rocni_zpravy/2013/Tiskova_zprava_NRL_pro_HIVAIDS_Trendy_a_vyskyt_HIVAIDS_CR_2013.pdf

27. Národní referenční laboratoř pro HIV/AIDS: Zpráva k 31. 4. 2014. Dostupné na: http://www.szu.cz/uploads/documents /CeM/HIV_AIDS/rocni_zpravy/2014/HIV_AIDS_03_2014.pdf

28. NDOWA, F., LUSTI-NARASIMHAN, M., UNEMO, M. The serious threat of multidrug-resistant and untreatable gonorrhoea: the pressing need for global action to control the spread of antimicrobial resistance, and mitigate the impact on sexual and reproductive health. Sex. Transm. Infect., 2012, 88, p. 317–318.

29. NICOLL, A., HAMERS, F. F. Are trends in HIV, gonorrhoea, and syphilis worsening in western Europe? BMJ, 2002, 324, p. 1324–1327.

30. Pohlavní nemoci, UZIS. Dostupné na: http://www.uzis.cz/katalog/zdravotnicka-statistika/pohlavni-nemoci.

31. RęTTINGEN, J. A., CAMERON, W., GARNETT, G. Systematic Review of the Epidemiologic Interactions Between Classic Sexually Transmitted Diseases and HIV: How Much Really Is Known? Sex. Transm. Dis., 2001, 28, p. 579–597.

32. SAVAGE, E. J., HUGHES, G., ISON, C. et al. Syphilis and gonorrhoea in men who have sex with men: a European overview. Euro. Surveill., 2009, 14, p. 1–9.

33. SAVAGE, E. J., MARSH, K., DUFFELL, S. et al. Rapid increase in gonorrhoea and syphilis diagnoses in England in 2011. Euro. Surveill., 2012, 17, p. 20224.

34. Sexually transmitted infections surveillance in Europe (ESSTI). Annual Report, 2008, 3, p. 1–86.

35. STEHLÍKOVÁ, D., STUPKA, J. Ročenka Národního programu HIV/AIDS v České republice 2009–2010. ÚZIS, 2011, s. 1–175.

36. STUPIANSKY, N. W., VAN DER POL, B., WILLIAMS J. A. et al. The natural history of incident gonococcal infection in adolescent women. Sex. Transm. Dis., 2011, 38, p. 750–754.

37. TAO, G., IRWING, K. L. Gonorrhea prevention and clinical care in the private sector: Lessons learned and priorities for quality improvement. Sex. Trans. Dis., 2006, 33, p. 652–662.

38. UNEMO, M. The 2012 European guideline on the diagnosis and treatment of gonorrhoea in adults recommends dual antimicrobial therapy. Euro. Surveill., 2012, 17, p. 20323.

39. VELICKO, I., UNEMO, M. Increase in reported gonorrhoea cases in Sweden, 2001–2008. Euro. Surveill., 2009, 14, 34, p. 19315.

40. World Health Organization 2011, Report of the expert consultation and review of the latest evidence to update guidelines for the management of sexually transmitted infections. p. 1–36. Dostupné na: http://www.who.int/reproductivehealth/publications/rtis/rhr_11_37/en/

41. World Health Organization, Department of Reproductive Health and Research, Global action plan to control the spread and impact of antimicrobial resistance in Neisseria gonorrhoeae. p. 1–40. Dostupné na: http://www.who.int/reproductivehealth/publications/rtis/9789241503501/en/

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