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Pretibial Myxoedema


Authors: J. Čechovičová;  L. Drlík
Authors‘ workplace: Dermatovenerologické oddělení, Šumperská nemocnice, a. s. přednosta prim. MUDr. Lubomír Drlík
Published in: Čes-slov Derm, 89, 2014, No. 5, p. 230-232
Category: Case interpretation

Overview

Pretibial myxoedema occurs in 1–10% of patients suffering from Graves’ disease. This condition is classified as mucinosis. The authors report a case of a 43-year-old woman after bilateral thyroidectomy for thyreotoxicosis with skin manifestation on the shins. Successful therapy included lymphatic drainage and topical corticosteroids.

Key words:
pretibial myxoedema – thyreopathy – deposits of mucin – therapy


Sources

1. BURGDORF, W. H. C., PLEWIG, G., WOLFF, H. H. Braun – Falco’s Dermatology, 3rd edition, Springer, Heidelberg, 2009, p. 1265–1266, ISBN 978-3-540-29312-5.

2. BURNS, T., BREATHNACH, S., COX, N. et al. Rook’s Textbook of Dermatology. 8th edition, Wiley-Blackwell: Singapore, 2012, p. 62.8–62.9, ISBN 978-1-4051-6169-5.

3. CETKOVSKÁ, P., PIZINGER, K., ŠTORK, J. Kožní změny u interních onemocnění. Grada: Praha, 2010, s. 90, ISBN 978-80-247-1004-4.

4. COUDERC, E., CANTE, V., RENAUD, O. et al. Graves’ dermopathy on the big toe. Ann. Dermatol. Venereol., 2013, 140, 5, p. 382–385.

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6. GOPIE, P., NARAYNSINGH, V. Severe pretibial myxedema. Int. J. Low Extrem. Wounds, 2011, 10, 2, p. 91–92.

7. CHEN, CH. T., LIN J. CH. Elephantiasic pretibial myxoedema. Indian J. Med. Res., 2013, 137, 3, p. 568.

8. RONGIOLETTI, F., DONATI, P., AMANTEA, A. Obesity – associated lymphoedematous mucinosis. J. Cutan. Pathol., 2009, 36, 10, p. 1089–1094.

9. SHINOHARA, M., HAMASAKI, Y., KATAYAMA, I. Refractory pretibial myxoedema with response to intralesional insulin-like growth factor 1 antagonist (octreotide): downregulation of hyaluronic acid production by the lesional fibroblasts. Br. J. Dermatol., 2000, 143, 5, p. 1083–1086.

10. TARASU, N., HIGA, H., KINJOU, Y. Treatment of pretibial myxedema (PTM) with topical steroid ointment application with sealing cover (steroid occlusive dressing technique: steroid ODT) in Graves’ patients. Intern. Med., 2010, 49, 7, p. 665–669.

11. TOKUDA, Y., KAWACHI, S., MURATA, H. Chronic obesity lymphoedematous mucinosis: three cases of pretibial mucinosis in obese patients with pitting oedema. Br. J. Dermatol., 2006, 154, 1, p. 157–161.

12. TONG, D. W., HO, K. K. Pretibial myxoedema presenting as a scar infiltrate. Australian J. Dermatol., 1998, 39, 4, p. 255–257.

13. VERMA, S., RONGIOLETTI, F., BRAUN–FALCO, M. Preradial myxedema in a euthyroid male: A distinct rarity. Dermatol. Online J., 2013, 19, 4, p. 9.

14. VIKTORINOVÁ, M., DITRICHOVÁ, D. Kožní projevy interních chorob. Interní medicína pro praxi., 2005, 5, p. 242–249.

15. WATSON, E. M. Localized (pretibial) myxoedema. Can. Med. Assoc. J., 1946, 54, 3, p. 260–265.

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