Lymphogranuloma Venereum: in the Czech Republic Already?
Authors:
S. Snake 1; V. Resl 1; J. Hrabák 2; D. Hrubá 3
Authors‘ workplace:
Dermatovenerologická klinika LFUK a FN Plzeň
přednosta prof. MUDr. Karel Pizinger, CSc.
1; Ústav mikrobiologie LFUK a FN Plzeň
přednosta RNDr. Karel Fajfrlík, Ph. D.
2; VIDIA-DIAGNOSTIKA s. r. o. – virologická laboratoř Praha
3
Published in:
Čes-slov Derm, 85, 2010, No. 3, p. 164-168
Category:
Venereology
Overview
The aim of the article is to call attention to the possibility of appearance of lymphogranuloma venereum in the Czech Republic in coincidence with an epidemic rise in Western Europe since 2003. The suspected diagnosis was not confirmed in the presented clinical case, however, it brought up questions about our laboratory diagnostic possibilities. It is important to think of lymphogranuloma venereum, especially in men who have sexual intercourse with men, travel to big European cities, with clinical findings including proctocolitis. The described case with painful genital ulcers and lymphadenopathy reminded, nowadays less common, clinical manifestation of this disease. In the end we introduce an examination protocol recommendation for the differential diagnostics of genital ulcers.
Key words:
Chlamydia trachomatis – genital ulcers – LGV – lymphadenopathy – lymphogranuloma venereum – proctocolitis – STI
Sources
1. Clad, A., Krause, W.: Urogenitale Chlamydien Infectionen bei Frau und Mann, Hautarzt 2007, 58, p. 13-17.
2. Cusini, M., Boneschi, V., Arancio, L., Ramoni, S., Venegoni, L., Gaiani, F., de Vries, HJC. Lymphogranuloma venereum: the Italian experience. Sex Transm Inf, 2009; 85, p.171 - 172.
3. Dean, D., Suchland, RJ., Stamm, WE. Evidence for long-term cervical persistence of Chlamydia trachomatis by omp1 genotyping. J Infect Dis, 2000 Sep;182(3), p. 909-916.
4. de Vries, HJC., Fennema, JS., Morré, SA. Lymphogranuloma venereum among men having sex with men; what have we learned so far? Sex Transm Inf, 2006; 82, p. 344.
5. de Vries, HJC., Smelov, V., Middelburg, JG., et al.. Delayed microbial cure of lymphogranuloma venereum proctitis with doxycycline treatment. Clin Infect Dis, 2009;48, p.53–56.
6. El Karoui, K., Méchaï, F., Ribadeau-Dumas, F., et al. Reactive arthritis associated with L2b lymphogranuloma venereum proctitis. Sex Transm Inf, 2009; 85, p.180–181.
7. Forrester, B., Pawade, J., Horner, P. The potential role of serology in diagnosing chronic lymphogranuloma venereum (LGV): a case of LGV mimicking Crohn’s disease. Sex Transm Inf, 2006; 82, p.139-140.
8. Hrubá, D. Chlamydiové infekce, Postgraduální medicína, 2004, 4, s. 395-399.
9. Hübschmann, K. Lymphogranuloma inguinale. Čas. lék. čes, 17, 1932.
10. Hübschmann, K. Positivní seroreakce na příjici u lymphogranuloma inguinale, Čas. lék. čes, 1110, 1941.
11. Jebbari, H., Alexander, S., Ward, H., Evans, B., Solomou, M., Thornton, A., Dean, G., White, J., French, P., Ison, C. for the UK LGV Incident Group. Update on lymphogranuloma venereum in the United Kingdom. Sexually transmitted infections, 2007, 83, p. 324-326.
12. Kuklová, I., Kojanová, M., Velčevský, P. Současný stav problematiky sexuálně přenosných onemocnění. Čes-slov Derm, 2008, 83, s.115-123.
13. McMillan A, van Voorst Vader PC, de Vries HJC; International Union against Sexually Transmitted Infections/World Health Organization. The 2007 European Guideline (International Union against Sexually Transmitted Infections/World Health Organization) on the management of proctitis, proctocolitis and enteritis caused by sexually transmissible pathogens. Int J STD AIDS, 2007;18(8), p. 514-520.
14. Meyer, T., Arndt, R., von Krosigk, A., Plettenberg, A. Repeated detection of lymphogranuloma venereum caused by Chlamydia trachomatis L2 in homosexual men in Hamburg. Sex Transm Inf, 2005; 81, p. 91-92.
15. Morré, SA., Ouburg, S., van Agtmael, MA., de Vries, HJC. Lymphogranuloma venereum diagnostics: from culture to real-time quadriplex polymerase chain reaction. Sex Transm Inf, 2008; 84, p. 252 - 253.
16. Procházka, P. Chlamydiové urogenitální infekce. Referátový výběr z dermatovenerologie Special I/2009, s. 36–40.
17. Quint, K., Porras, C., Safaeian, M., González, P., Hildesheim, A., Quint, W., van Doorn, LJ., Silva, S., Melchers, W., Schiffman, M., Rodríguez, AC., Wacholder, S., Freer, E., Cortes, B., Herrero, R. Evaluation of a novel PCR-based assay for detection and identification of Chlamydia trachomatis serovars in cervical specimens. J Clin Microbiol, 2007; 45(12), p. 3986-3991.
18. Resl,V., Voltr, J., Pizinger, K. Venerologie, UK Praha 1994, 1996.
19. Roubalová, K., Janečková, L. Doporučené metody pro diagnostiku C. trachomatis. Zprávy CEM, 2006, 15, s. 510-514.
20. Sayada, C., Denamur, E., Orfila, J., Catalan, F., Elion, J. Rapid genotyping of the Chlamydia trachomatis major outer membrane protein by the polymerase chain reaction. FEMS Microbiol Lett, 1991 Sep 15, 67(1), p.73-78.
21. Sethi, G., Allason-Jones, E., Richens, J., Annan, NT., Hawkins, D., Ekbote, A., Alexander, S., White, J. Lymphogranuloma venereum presenting as genital ulceration and inguinal syndrome in men who have sex with men in London, UK. Sex Transm Inf, 2009;85, p. 165-170.
22. Schaeffer, A., Henrich, B.: Rapid detection of Chlamydia trachomatis and typing of the Lymphogranuloma venereum associated L-Serovars by TaqMan PCR. BMC Infect Dis, 2008; 8, p. 56.
23. Spenatto, N., Boulinguez, S., Barbeyrac, B., Viraben, R. First case of „bubonulus“ in L2 lymphogranuloma venereum. Sex transm inf, 2007, 83, p. 337-338.
24. Sylvan, SPE., Hedlund, J. Efficacy of partner notification for Chlamydia trachomatis among young adults in youth health centres in Uppsala County, Sweden. JEADV, 2009, 23(5), p. 517-522.
25. Štork, J. et al. Dermatovenerologie. Galén Praha 2008.
26. Ward, H., Miller, RF. Lymphogranuloma venereum: here to stay? Sex Transm Inf, 2009; 85, p. 157.
Labels
Dermatology & STDs Paediatric dermatology & STDsArticle was published in
Czech-Slovak Dermatology
2010 Issue 3
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