#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

The Significance of Sentinel Node Examination in Melanoma: Part I. A Review


Authors: I. Krajsová 1;  I. Vítková 3;  J. Šuk 2;  I. Procházková 1;  T. Šuková 1;  A. Vokáčová 4
Authors‘ workplace: Dermatovenerologická klinika VFN a 1. LF UK přednosta prof. MUDr. J. Štork, CSc. 1;  Chirurgická klinika VFN a 1. LF UK přednosta doc. MUDr. J. Šváb, CSc. 2;  Patologicko-anatomický ústav VFN a 1. LF UK přednosta prof. MUDr. C. Povýšil, DrSc. 3;  Ústav nukleární medicíny VFN a 1. LF UK přednosta prof. MUDr. M. Šámal, DrSc. 4
Published in: Čes-slov Derm, 80, 2005, No. 3, p. 140-146
Category: Reviews

Overview

The sentinel lymph node (SLN) is the lymph node localized next to the tumour in the direction of lymphatic drainage. Though it is the first lymph node to which the metastatic cells could migrate through lymphatics. The regional lymphatic basin and SLN localization is identified by preoperative lymphoscintigraphy, followed by surgical removal of the node identified by the vital blue dye and labelled radiocolloid.

Removed lymph node is examined by pathologist according to the recommended scheme, using basic hematoxylin-eosin staining and immunohistochemical methods. Excision and histopathological examination helps to precise the disease staging and to decide about possible future treatment strategy. The SLN histopathological state defines with high probability the state of other regional lymph nodes. At present, the SLN examination is considered to be a standard examination procedure enabling to precise disease staging. If all indication and contraindication restrictions are respected, it represents the method with minimal burden and neglectable complications for the patient.

Key words:
melanoma – sentinel lymph node – indications and contraindications – significance of examination


Labels
Dermatology & STDs Paediatric dermatology & STDs
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#